Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof

• US 8,703,737 B2
• Filed: 12/22/2011
• Issued: 04/22/2014
• Est. Priority Date: 12/31/2010
• Status: Active Grant

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Buck, Rachael, Duska-McEwen, Geralyn O., Schaller, Joseph P.
• Primary Examiner(s): Peselev, Elli
• Application Number:
  US13/334,995
• Publication Number:
  US 20120172327A1
• Time in Patent Office: 852 Days
• Field of Search: 514/53
• US Class Current: 514/54
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/3202 Prebiotics, ingredients fermented in the gastrointestinal tract by beneficial microflora
• CPC Class Codes: A23V 2200/324 having an effect on the immune system
• CPC Class Codes: A23V 2250/1882 Polyunsaturated fatty acids
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 31/7016 Disaccharides, e.g. lactose, lactulose lactobionic acid A61K31/7032
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants

Abstract

Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.

Claims

1. A method of reducing inflammation in an infant, toddler, or child in need thereof, the method comprising administering to the infant, child or toddler a composition comprising the human milk oligosaccharide 2′

-fucosyllactose in a concentration of from about 0.001 mg/mL to about 20 mg/mL, from about 0.001 μ

g/mL to about 5 μ

g/mL of lycopene, and from about 0.025 mg/mL to about 0.130 mg/mL of a long chain polyunsaturated fatty acid.

2. The method of claim 1, wherein the long chain polyunsaturated fatty acid is selected from the group consisting of linoleic acid, linolenic acid, arachidonic acid, docosahexaenoic acid, eicosapentaenoic acid, docosapentaenoic acid, and combinations thereof.

3. The method of claim 1, wherein the long chain polyunsaturated fatty acid is docosahexaenoic acid.

4. The method of claim 1, wherein the 2′

-fucosyllactose is present in a concentration of from about 0.01 mg/mL to about 1 mg/mL.

5. The method of claim 1, wherein the inflammation is an immune response associated with a respiratory virus.