Electrochemical analyte sensor
First Claim
1. An in vivo glucose sensor, comprising:
- a substrate having a distal region for partial implantation through a skin surface and a proximal region, the substrate including at least a first surface and a second surface;
a working electrode disposed on the distal region of the first surface of the substrate and configured to be positioned in fluid contact with interstitial fluid under the skin surface;
a counter electrode disposed on the distal region of the second surface of the substrate;
a plurality of conductive contacts disposed on the proximal region of the substrate and on the first surface of the substrate, wherein a first one of the plurality of conductive contacts is in electrical communication with the work electrode, and a second one of plurality of conductive contacts is in electrical communication with the counter electrode;
at least one via formed through the substrate that electrically connects the counter electrode to the second one of the plurality of conductive contacts;
a sensing layer proximate to the working electrode; and
a mass transport limiting layer proximate to the working electrode;
wherein a flexibility of sensor is varied along a continuum of the substrate
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Accused Products
Abstract
An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.
600 Citations
25 Claims
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1. An in vivo glucose sensor, comprising:
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a substrate having a distal region for partial implantation through a skin surface and a proximal region, the substrate including at least a first surface and a second surface; a working electrode disposed on the distal region of the first surface of the substrate and configured to be positioned in fluid contact with interstitial fluid under the skin surface; a counter electrode disposed on the distal region of the second surface of the substrate; a plurality of conductive contacts disposed on the proximal region of the substrate and on the first surface of the substrate, wherein a first one of the plurality of conductive contacts is in electrical communication with the work electrode, and a second one of plurality of conductive contacts is in electrical communication with the counter electrode; at least one via formed through the substrate that electrically connects the counter electrode to the second one of the plurality of conductive contacts; a sensing layer proximate to the working electrode; and a mass transport limiting layer proximate to the working electrode; wherein a flexibility of sensor is varied along a continuum of the substrate - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An in vivo glucose sensor, comprising:
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a substrate having a distal region for partial implantation through a skin surface and a proximal region, the substrate including at least a first surface and a second surface; a working electrode disposed on the distal region on the first surface of the substrate and configured to be positioned in fluid contact with interstitial fluid under the skin surface; a counter electrode disposed on the distal region on the second surface of the substrate; a plurality of conductive contacts disposed on the proximal region of the substrate and on the first surface of the substrate, wherein a first one of the plurality of conductive contacts is in electrical communication with the working electrode, and a second one of the plurality of conductive contacts is in electrical communication with the counter electrode; at least one via formed through the substrate that electrically connects the counter electrode to the second one of the plurality of conductive contacts; and a sensing layer proximate to the working electrode; wherein a length of the sensor is between 0.3 cm and 5 cm, and a flexibility of the sensor is varied along a continuum of the substrate. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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17. An in vivo glucose sensor, comprising:
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a substrate having a distal region for partial implantation through a skin surface and a proximal region, the substrate including at least a first surface and a second surface; a working electrode disposed on the distal region on the first surface of the substrate; a counter electrode disposed on the distal region on the second surface of the substrate; a plurality of conductive contacts disposed on the proximal region of the substrate and on the first surface of the substrate, wherein a first one of the plurality of conductive contacts is in electrical communication with the working electrode, and a second one of the plurality of conductive contacts is in electrical communication with the counter electrode; at least one via formed through the substrate that electrically connects the counter electrode to the second one of the plurality of conductive contacts; and a sensing layer proximate to the working electrode; wherein a flexibility of the sensor is varied along a continuum of the substrate. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25)
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Specification