System for patent interactive neural stimulation with robotic facilitation of limb movement

• US 8,706,241 B2
• Filed: 12/20/2010
• Issued: 04/22/2014
• Est. Priority Date: 10/19/2005
• Status: Active Grant

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Gliner, Bradford Evan, Firlik, Andrew D, Sheffirld, W Douglas, Sloan, Leif R
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US12/973,471
• Publication Number:
  US 20110092882A1
• Time in Patent Office: 1,219 Days
• Field of Search: None
• US Class Current: 607/48
• CPC Class Codes: A61B 5/16 Devices for psychotechnics using teaching or educational appliances G09B1/00 - G09B7/00; Testing reaction times ; Devices for evaluating the psychological state
• CPC Class Codes: A61B 5/18 for vehicle drivers or machine operators
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61F 2002/704 computer-controlled, e.g. robotic control
• CPC Class Codes: A61M 2205/05 combined with other kinds of therapy
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2230/63 Motion, e.g. physical activity
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/361 Phantom sensations, e.g. tinnitus
• CPC Class Codes: A61N 1/36103 Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 20/70 : relating to mental therapies, e.g. psychological therapy or autogenous training

Abstract

Systems and methods for patient interactive neural stimulation and/or chemical substance delivery are disclosed. A method in accordance with one embodiment of the invention includes affecting a target neural population of the patient by providing to the patient at least one of an electromagnetic signal and a chemical substance. The method can further include detecting at least one characteristic of the patient, with the characteristic at least correlated with the patient'"'"'s performance of an adjunctive therapy task that is performed in association with affecting the target neural population. The method can still further include controlling at least one parameter in accordance with which the target neural population is affected, based at least in part on the detected characteristic.

Claims

1. A system for facilitating limb movement in a patient that is suffering from or has suffered a neurological disorder or event;

the system comprising;

a neural stimulation system having an implantable pulse generator that is coupled to at least one electrode assembly capable of delivering electrical pulses to the patient'"'"'s brain;

a robotic system configured to facilitate movement of the patient'"'"'s limb;

a control system operatively coupled to the robotic system and the neural stimulation system, the control system having a computer-readable medium having instructions, wherein the instructions include;

automatically receiving information from the robotic system, the information being correlated with the patient'"'"'s performance of a task using the robotic system; and

based at least in part on the information received from the robotic system, automatically controlling a parameter in accordance with the neural stimulation system or the robotic system to facilitate limb movement.

2. The system of claim 1 wherein the robotic system comprises at least one robotic element that is positioned to resist patient movement under direction of the control system.

3. The system of claim 1 wherein the robotic system comprises the at least one robotic element that is positioned to assist patient movement under direction of the control system.

4. The system of claim 1 wherein the patient has suffered a stroke.

5. The system of claim 1 wherein the patient is suffering from Parkinson'"'"'s disease.

7. The system of claim 1 wherein the electrode assembly is positionable under the skull and over the dura of a cortical target selected from a group consisting of motor cortex, premotor cortex, somatosensory cortex, and prefrontal cortex.

8. The system of claim 1 further comprising a secondary stimulation system.

9. The system of claim 1 wherein the robotic system comprises an element or elements to assist in restoration of hand movement, arm movement or a combination thereof.

10. The system of claim 9 wherein the element comprises at least one arm member, at least one elbow member coupled to the at least one arm member to form rotational axes, a set of actuators configured to facilitate arm member motion, a set of sensors configured to sense and quantify position, force, speed, of arm members or elbow joints, at least one gripping portion configured for grasping, or a combination thereof.

11. The system of claim 1 wherein the robotic system comprises an element or elements to sense, analyze, monitor or a combination thereof the patient'"'"'s interaction with an object of daily living.

12. The system of claim 11 wherein the element is associated with a wearable item by the patient.

13. The system of claim 12 wherein the wearable item is a glove having the element configured as a set of bands that is proximate to a portion of the patient'"'"'s fingers, hand, wrist, arm or a combination thereof.

14. The system of claim 12 wherein the wearable item is a sleeve having the element configured as a set of bands that is proximate to a portion of the patient'"'"'s fingers, hand, wrist, arm or a combination thereof.

6. The system of claim wherein the patient is suffering from hemiparesis, spasticity, neglect, bradykinesia or a combination thereof.