Health data dynamics, its sources and linkage with genetic/molecular tests
First Claim
1. A method useful in monitoring of at least one feature of a wave signal selected from blood pressure, cardiac output and vascular activity comprising:
- placing at least one sensor adapted for registering at least one mechanical movement on the surface of a torso in the vicinity of at least one major blood vessel;
collecting information from said at least one sensor over multiple cardiac cycles;
processing said information by at least one signal processing method selected from time aligning the information registered from multiple cardiac cycles with respect to a fiducial point corresponding to the same phase of each cardiac cycle, signal averaging, filtering, pattern recognition, and time-series analysis to improve the signal-to-noise ratio of collected information respecting said at least one feature of a wave signal being monitored; and
adjusting at least one point-by-point comparison of the signals recorded during the same phase of a cardiac cycle at different anatomical locations, time alignment of the signals by finding the time lag corresponding to the maximum value of the cross-correlation function, normalization of the signals by finding the stretching/compression coefficients that maximize the cross-correlation function and normalizing the waveform duration/amplitude by these coefficients, rejection of the noisy or uncharacteristic signals that deviate from the standard pressure-waveform template, averaging of the signals registered by several sensors with a time alignment and normalization as necessary, a mathematical decomposition, pattern recognition, principal component analysis and other orthogonal and non-orthogonal transforms that extract typical features of the pressure waveforms.
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Abstract
Method and system for the analysis and source localization of the dynamical patterns in medical and health data, and linking such dynamical patterns with the individual'"'"'s genetic and/or molecular data. The invention makes use of optimally positioned sensors (sensor arrays) providing input data for signal processing, time-series analysis, pattern recognition and mathematical modeling to facilitate dynamical tracking of systemic arterial pressure without a pressure cuff, local vascular activity, electrocardiographic (ECG), respiratory, physical, muscular, gastrointestinal and neural activity, temperature and other physiological/health data. The invention also facilitates separation of local signals (such as local aneurisms or local vascular activity) from non-local, central or systemic patterns (e.g. systemic blood pressure). In addition, the invention improves identification of dynamical patterns associated with a specific genotype/disorder for screening, personalized risk assessment, diagnosis and treatment control. The system can be implemented in a specialized processor, such as an ambulatory blood pressure monitor, Electrocardiograph, Holter monitor located outside subject'"'"'s body or implanted inside the body, mobile/cell phone or Smart Phone/Personal Digital Assistant, computer or computer network (the Internet), including wireless or mobile network. The system can be also linked to the electronic health/medical records and other databases.
9 Citations
19 Claims
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1. A method useful in monitoring of at least one feature of a wave signal selected from blood pressure, cardiac output and vascular activity comprising:
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placing at least one sensor adapted for registering at least one mechanical movement on the surface of a torso in the vicinity of at least one major blood vessel; collecting information from said at least one sensor over multiple cardiac cycles; processing said information by at least one signal processing method selected from time aligning the information registered from multiple cardiac cycles with respect to a fiducial point corresponding to the same phase of each cardiac cycle, signal averaging, filtering, pattern recognition, and time-series analysis to improve the signal-to-noise ratio of collected information respecting said at least one feature of a wave signal being monitored; and adjusting at least one point-by-point comparison of the signals recorded during the same phase of a cardiac cycle at different anatomical locations, time alignment of the signals by finding the time lag corresponding to the maximum value of the cross-correlation function, normalization of the signals by finding the stretching/compression coefficients that maximize the cross-correlation function and normalizing the waveform duration/amplitude by these coefficients, rejection of the noisy or uncharacteristic signals that deviate from the standard pressure-waveform template, averaging of the signals registered by several sensors with a time alignment and normalization as necessary, a mathematical decomposition, pattern recognition, principal component analysis and other orthogonal and non-orthogonal transforms that extract typical features of the pressure waveforms. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system for monitoring at least one feature of a wave signal selected from blood pressure, cardiac output and vascular activity comprising:
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at least one sensor adapted for registering at least one mechanical movement on the surface of a torso in the vicinity of a major blood vessel; at least one acquisition and communication unit for receiving and recording information from said at least one sensor over multiple cardiac cycles; and at least one processing unit adapted to process said information by at least one signal processing method selected from time aligning the information registered from multiple cardiac cycles with respect to a fiducial point corresponding to the same phase of each cardiac cycle, signal averaging, filtering, pattern recognition, and time-series analysis to improve the signal-to-noise ratio of collected information respecting said at least one feature of a wave signal being monitored, and further adapted to process said information from several anatomical locations using at least one processing method selected from point-by-point comparison of the signals recorded during the same phase of a cardiac cycle, time-alignment of the signals by finding the time lag corresponding to the maximum value of the cross-correlation function, normalization of the signals by finding the stretching/compression coefficients that maximize the cross-correlation function and normalizing the waveform duration/amplitude by these coefficients, rejection of the noisy or uncharacteristic signals that deviate from the standard pressure-waveform template, averaging of the signals registered by several sensors at different anatomical locations with a time-alignment and normalization as necessary, a mathematical decomposition, pattern recognition, principal component analysis and other orthogonal and non-orthogonal transforms that extract typical features of the pressure waveforms. - View Dependent Claims (12, 13, 14)
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15. A method for monitoring at least one vital sign selected from blood pressure, cardiac output and vascular activity comprising:
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positioning at least one accelerometer sensor on an individual in the vicinity of at least one major blood vessel; collecting and recording data relating to the individual'"'"'s blood pressure wave at different anatomical locations from said at least one accelerometer sensor; and processing said data by at least one signal processing method selected from time aligning the information registered from multiple cardiac cycles with respect to a fiducial point corresponding to the same phase of each cardiac cycle, signal averaging, filtering, pattern recognition, and time-series analysis, and further processing said data with respect to said anatomical locations using at least one processing method selected from point-by-point comparison of the signals recorded during the same phase of a cardiac cycle, time-alignment of the signals by finding the time lag corresponding to the maximum value of the cross-correlation function, normalization of the signals by finding the stretching/compression coefficients that maximize the cross-correlation function and normalizing the waveform duration/amplitude by these coefficients, rejection of the noisy or uncharacteristic signals that deviate from the standard pressure-waveform template, averaging of the signals registered by several sensors at different anatomical locations with a time-alignment and normalization as necessary, a mathematical decomposition, pattern recognition, principal component analysis and other orthogonal and non-orthogonal transforms that extract typical features of the pressure waveforms. - View Dependent Claims (16, 17)
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18. A system for monitoring at least one vital sign selected from blood pressure, cardiac output and vascular activity comprising:
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at least one accelerometer sensor adapted for registering at least one mechanical movement on the surface of a torso in the vicinity of a major blood vessel; at least one acquisition and communication unit for receiving and recording information from said at least one sensor over multiple cardiac cycles; and at least one processing unit adapted to process said information by at least one signal processing method selected from time aligning the information registered from multiple cardiac cycles with respect to a fiducial point corresponding to the same phase of each cardiac cycle, signal averaging, filtering, pattern recognition, and time-series analysis, and further adapted to process said information from several anatomical locations using at least one processing method selected from point-by-point comparison of the signals recorded during the same phase of a cardiac cycle at different anatomical locations, time alignment of the signals by finding the time lag corresponding to the maximum value of the cross-correlation function, normalization of the signals by finding the stretching/compression coefficients that maximize the cross-correlation function and normalizing the waveform duration/amplitude by these coefficients, rejection of the noisy or uncharacteristic signals that deviate from the standard pressure-waveform template, averaging of the signals registered by several sensors with a time alignment and normalization as necessary, a mathematical decomposition, pattern recognition, principal component analysis and other orthogonal and non-orthogonal transforms that extract typical features of the pressure waveforms, to improve the signal-to-noise ratio of collected information respecting said at least one vital sign being monitored. - View Dependent Claims (19)
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Specification