Scalable parallel gene therapy injector array

• US 8,708,965 B2
• Filed: 11/17/2009
• Issued: 04/29/2014
• Est. Priority Date: 11/17/2008
• Status: Active Grant

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Boyden, Edward S., Chan, Stephanie
• Primary Examiner(s): BOUCHELLE, LAURA A
• Application Number:
  US12/619,685
• Publication Number:
  US 20100152662A1
• Time in Patent Office: 1,624 Days
• Field of Search: 604/46, 604/47, 604/131, 604/151, 604/173, 604/174, 604/93.01, 204/604
• US Class Current: 604/173
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons

Abstract

A scalable parallel injector array has a support structure for holding injector tubes in a spatial pattern in order to enable delivery of fluidic materials simultaneously to a group of specific target areas in the brain or a body part. Each injector is individually connectible at one end to a displacement-controlled pump and is designed at the other end to be inserted into the brain or body part. The injector tubes are connected to the pump by fluid-filled tubing. The spatial pattern is patient- and/or application-customizable, and the length of the injector tubes is customizable in order to more precisely reach individual target areas. A clamping device may be used to attach the injector array to a stereotaxic arm or other support structure. The action of the pump permits controlled simultaneous delivery of the fluidic materials to the target areas.

Claims

1. An injector array, comprising:

a plurality of capillary tubes of varying lengths, each capillary tube being individually connectible at a proximal end to a displacement-controlled pump, each capillary tube being adapted at a distal end for insertion into a brain or body part, each capillary tube being further adapted for delivery of fluidic materials through the distal end to the brain or body part, wherein the length of each individual capillary tube is individually determined according to the location of a respective one of a plurality of specific target areas in the brain or body part and at least some of the individual capillary tubes are of different lengths than others of the individual capillary tubes;

a support structure for holding the plurality of capillary tubes such that their distal ends, taken together, terminate in a three-dimensional spatial pattern that permits delivery of the fluidic materials in parallel to the plurality of specific target areas in the brain or body part; and

a stereotaxic device to which the support structure is attachable, the stereotaxic device being configured to control the angular orientation of the support structure with respect to the brain or body part so that the distal end of each capillary tube is positioned at its respective target area.

2. The injector array of claim 1, wherein the capillary tubes are connectible to the displacement-controlled pump by means of tubing.

3. The injector array of claim 1, wherein the spatial pattern is patient-customizable.

4. The injector array of claim 1, wherein the number of capillary tubes is customizable.

5. The injector array of claim 1, wherein the support structure is a custom-milled board through which the capillary tubes pass.

6. An injector array system, comprising:

a displacement-controlled pumping device;

a plurality of tube injectors of varying lengths, each tube injector being individually connected at a proximal end to fluid-filled tubing connected to the displacement-controlled pumping device, each tube injector being adapted at a distal end for insertion into a brain or body part to permit delivery of fluidic materials through the distal end to the brain or body part, each tube injector being controllable by the displacement-controlled pumping device, wherein the length of each individual tube injector is individually determined according to the location of a respective one of a plurality of specific target areas in the brain or body part and at least some of the individual tube injectors are of different lengths than others of the individual tube injectors;

an injector array support structure for holding the plurality of tube injectors in parallel such that their distal ends, taken together, terminate in a three-dimensional spatial pattern designed to permit simultaneous delivery of the fluidic materials to the specific target areas in the brain or body part;

a stereotaxic device to which the support structure is attachable, the stereotaxic device being configured to control the angular orientation of the support structure with respect to the brain or body part so that the distal end of each tube injector is positioned at its respective target area; and

a clamping device for attaching the injector array support structure to the stereotaxic device.

7. The injector array system of claim 6, the displacement-controlled pumping device further comprising a syringe associated with each connected tube injector, each syringe being connected to the associated tube injector via the tubing.

8. The injector array system of claim 6, wherein the spatial pattern is at least one of patient-customizable or application-customizable.

9. The injector array system of claim 6, wherein the number of tube injectors is customizable.

10. The injector array system of claim 6, wherein the support structure is a custom-milled board through which the tube injectors pass.

11. A system adapted for delivery of fluidic materials to target areas of the brain or body, comprising:

a plurality of injectors of varying lengths, each injector being individually connectible at a proximal end to a displacement-controlled pumping device, each injector being adapted at a distal end for insertion into a brain or body part to permit delivery of fluidic materials through the distal end to the brain or body part, each injector being controllable by the displacement-controlled pumping device, wherein the length of each individual injector is individually determined according to the location of a respective one of a plurality of specific target areas in the brain or body part and at least some of the individual injectors are of different lengths than others of the individual injectors;

an injector array support structure for holding the plurality of injectors in parallel such that their distal ends, taken together, terminate in a three-dimensional spatial pattern designed to permit simultaneous delivery of the fluidic materials to the specific target areas in the brain or body part; and

a stereotaxic device for attaching to the injector array support structure, the stereotaxic device being configured to control the angular orientation of the support structure with respect to the brain or body part so that the distal end of each injector is positioned at its respective target area.

12. The system of claim 11, further comprising fluid-filled tubing connecting each injector to the pumping device.

13. The system of claim 12, further comprising the displacement-controlled pumping device, the pumping device further comprising a syringe associated with each connected injector, each syringe being connected to the associated injector via the tubing.

14. The system of claim 11, wherein the spatial pattern is at least one of patient-customizable or application-customizable.

15. The system of claim 11, wherein the number of injectors is customizable.

16. The system of claim 11, wherein the support structure is a custom-milled board through which the injectors pass.