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Methods and device for synergistic mitigation of reperfusion injury after an ischemic event

  • US 8,708,996 B2
  • Filed: 04/29/2011
  • Issued: 04/29/2014
  • Est. Priority Date: 04/30/2010
  • Status: Expired due to Fees
First Claim
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1. A method for mitigating reperfusion injury to a tissue in a subject suffering from an ischemic event in a blood vessel, the method comprising:

  • locally administering a calpain inhibitor to an ischemic blood vessel during a cycle of inflation and deflation of a balloon within the ischemic blood vessel during a postconditioning procedure,wherein the calpain inhibitor is locally administered to an area of the blood vessel distal to a lesion.

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