Method and device for treatment of mitral insufficiency

• US 8,709,074 B2
• Filed: 02/06/2012
• Issued: 04/29/2014
• Est. Priority Date: 06/30/1999
• Status: Expired due to Fees

• Current Assignee: Edwards Lifesciences AG (Edwards Lifesciences Corporation)
• Original Assignee: Edwards Lifesciences AG (Edwards Lifesciences Corporation)
• Inventors: Solem, Jan Otto, Kimblad, Per-Ola, von Oepen, Randolf, Quint, Bodo, Seibold, Gerd, Michlitsch, Kenneth J., Ha, Suk-Woo, Eckert, Karl-Ludwig, Joergensen, Ib, Nielsen, Stevan
• Primary Examiner(s): Isabella, David
• Assistant Examiner(s): SCHILLINGER, ANN M
• Application Number:
  US13/366,540
• Publication Number:
  US 20120165924A1
• Time in Patent Office: 813 Days
• Field of Search: 623 111- 154
• US Class Current: 623/1.49
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/2451 Inserts in the coronary sinus for correcting the valve shape
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2002/826 more than one stent being applied sequentially
• CPC Class Codes: A61F 2002/828 Means for connecting a plurality of stents allowing flexibility of the whole structure
• CPC Class Codes: A61F 2002/8483 Barbs
• CPC Class Codes: A61F 2210/0004 bioabsorbable

Abstract

A device for treatment of mitral annulus dilation is disclosed, wherein the device comprises two states. In a first of these states the device is insertable into the coronary sinus and has a shape of the coronary sinus. When positioned in the coronary sinus, the device is transferable to the second state assuming a reduced radius of curvature, whereby the radius of curvature of the coronary sinus and the radius of curvature as well as the circumference of the mitral annulus is reduced.

Claims

1. A method of treating dilatation of a mitral valve annulus, comprising:

advancing a catheter into a coronary sinus, the catheter carrying an expandable implant that is in a radially collapsed configuration during the advancing, the implant comprising a distal portion, a proximal portion, and a central portion, the implant having a length extending from a proximal end to a distal end of the implant;

positioning the implant in a desired location in the coronary sinus;

expanding the distal and proximal implant sections of the implant in the coronary sinus;

permitting the distal and proximal implant sections to become endothelialized in the coronary sinus; and

after permitting the distal and proximal implant sections to become endothelialized, decreasing the length of the implant by radially expanding the central section of the implant, thereby altering a shape of the coronary sinus by decreasing the length of the implant, thereby reducing a circumference of the mitral valve annulus.

2. The method of claim 1, further comprising expanding the distal implant section within the coronary sinus before expanding the proximal implant section within the coronary sinus.

3. The method of claim 1, wherein the central section is retained in a contracted state by a biodegradable structure.

4. The method of claim 3, wherein the biodegradable structure comprises a suture.

5. A method of treating dilatation of a mitral valve annulus, comprising:

advancing a catheter into a coronary sinus, the catheter carrying an expandable implant that is in a radially collapsed configuration during the advancing, the implant having a length extending from a proximal end to a distal end of the implant, the implant comprising a distal section and a proximal section;

positioning the implant in a desired location in the coronary sinus;

expanding the implant in the coronary sinus;

permitting the proximal section and distal section to become endothelialized; and

after the proximal section and distal section become endothelialized, altering a shape of the coronary sinus by decreasing the length of the implant, thereby reducing a circumference of the mitral valve annulus.

6. The method of claim 5, further comprising expanding the distal implant section within the coronary sinus before expanding the proximal implant section within the coronary sinus.

7. The method of claim 5, wherein the implant is retained in a contracted state by a biodegradable structure.

8. The method of claim 5, wherein the implant comprises a central section extending between the proximal section and distal section.

9. The method of claim 8, wherein the central section is retained in a contracted state by a biodegradable structure.

10. The method of claim 9, wherein the biodegradable structure comprises a suture.

11. The method of claim 8, wherein the central section comprises a radially expandable structure configured to decrease in length when radially expanded, and wherein altering a shape of the coronary sinus by decreasing the length of the implant comprises radially expanding the central section.