Inducement of organogenetic tolerance for pancreatic xenotransplant
First Claim
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1. A method for treating diabetes mellitus in a subject in need thereof comprising:
- implanting a porcine pancreatic primordium, or a portion thereof, in an amount effective to induce tolerance to porcine islet cells comprising mature antigen-presenting cells, into a non-porcine mammalian subject;
waiting a period of time sufficient to induce tolerance to porcine islet cells comprising mature antigen-presenting cells; and
implanting porcine islet cells comprising mature antigen-presenting cells into the non-porcine mammalian subject.
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Abstract
Provided herein is an approach to establish organogenetic tolerance via prior transplantation of pig embryonic pancreas, thereby enabling subsequent implantation of porcine islets in a subject without the need for immune-suppression. In one aspect of the invention, porcine pancreatic primordia are implanted into a mammalian subject, and after a period of time sufficient to induce tolerance, porcine islet cells are implanted in the subject.
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22 Claims
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1. A method for treating diabetes mellitus in a subject in need thereof comprising:
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implanting a porcine pancreatic primordium, or a portion thereof, in an amount effective to induce tolerance to porcine islet cells comprising mature antigen-presenting cells, into a non-porcine mammalian subject; waiting a period of time sufficient to induce tolerance to porcine islet cells comprising mature antigen-presenting cells; and implanting porcine islet cells comprising mature antigen-presenting cells into the non-porcine mammalian subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification