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Once daily formulations of tetracyclines

DC CAFC
  • US 8,709,478 B2
  • Filed: 06/18/2013
  • Issued: 04/29/2014
  • Est. Priority Date: 04/07/2003
  • Status: Expired due to Term
First Claim
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1. A method for treating rosacea in a mammal in need thereof, comprising administering an oral pharmaceutical composition consisting of (i) an immediate release formulation (IR) comprising about 30 mg doxycycline;

  • (ii) a delayed release formulation (DR) comprising about 10 mg doxycycline; and

    (iii) a pharmaceutically acceptable excipient selected from the group consisting of binder, disintegration agent, filling agent, surfactant, solubilizer, stabilizer, plasticizer, lubricant, enteric polymers, and combinations thereof; and

    (iv) optionally, a controlling coat, overcoating layer, a core, and combinations thereof, wherein doxycycline is the sole active ingredient and the total amount of doxycyline in the composition is about 40 mg.

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