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Biological analysis arrangement and approach therefor

  • US 8,709,788 B2
  • Filed: 11/19/2012
  • Issued: 04/29/2014
  • Est. Priority Date: 09/16/2002
  • Status: Expired due to Fees
First Claim
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1. An apparatus comprising:

  • an integrated circuit chip configured and arranged as a one-sided biological sensing architecture that includesa substrate of the integrated circuit chip having a first side;

    a plurality of test sites that are recessed into the first side of the integrated circuit chip substrate and configured and arranged in a planar array;

    a plurality of photodiodes that are integrated into the recesses of the plurality of test sites and that are configured and arranged with a diffusion doping region having a dopant concentration and junction depth sufficient to detect firefly luciferase light produced during a pyrosequencing reaction within the plurality of test sites and generated from a sample contained within the test sites;

    an analog to digital converter circuit fabricated as part of the integrated circuit chip and configured and arranged to convert analog voltages from the plurality of photodiodes into digital values; and

    a memory circuit configured and arranged to store the digital values and that is fabricated as part of the integrated circuit chip.

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