Stable liquid VEGF antagonist formulations
First Claim
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1. A stable liquid formulation of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist, comprising 10-100 mg/ml of a fusion protein comprising amino acids 27-457 of SEQ ID NO:
- 4;
5 mM phosphate and 5 mM citrate, at a pH of about 6.0-6.5;
about 20% sucrose;
about 50-100 mM NaCl; and
about 0.1% polysorbate 20.
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Abstract
Formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided including a pre-lyophilized formulation, a reconstituted lyophilized formulation, and a stable liquid formulation. Preferably, the fusion protein has the sequence of SEQ ID NO:4.
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6 Claims
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1. A stable liquid formulation of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist, comprising 10-100 mg/ml of a fusion protein comprising amino acids 27-457 of SEQ ID NO:
- 4;
5 mM phosphate and 5 mM citrate, at a pH of about 6.0-6.5;
about 20% sucrose;
about 50-100 mM NaCl; and
about 0.1% polysorbate 20. - View Dependent Claims (2, 3, 4, 5, 6)
- 4;
Specification