Matching geometry generation and display of mammograms and tomosynthesis images

• US 8,712,127 B2
• Filed: 03/13/2012
• Issued: 04/29/2014
• Est. Priority Date: 11/15/2004
• Status: Active Grant

• Current Assignee: Hologic Incorporated
• Original Assignee: Hologic Incorporated
• Inventors: Ren, Baorui, Ruth, Christopher, Smith, Andrew P., Wilson, Kevin, Stein, Jay A.
• Primary Examiner(s): Bayat, Ali
• Application Number:
  US13/418,851
• Publication Number:
  US 20120195484A1
• Time in Patent Office: 777 Days
• Field of Search: 382/128, 382/131, 382/132, 378/23, 378/37, 378/68, 378/154, 378/152, 378/163, 378/165, 378/101
• US Class Current: 382/128
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: G06F 18/22 Matching criteria, e.g. proximity measures
• CPC Class Codes: G06T 11/006 Inverse problem, transformation from projection-space into object-space, e.g. transform methods, back-projection, algebraic methods
• CPC Class Codes: G06T 11/60 Editing figures and text; Combining figures or text
• CPC Class Codes: G06T 2207/10081 Computed x-ray tomography [CT]
• CPC Class Codes: G06T 2207/30068 Mammography; Breast
• CPC Class Codes: G06T 3/02 Affine transformations for image registration G06T3/147; for image mosaicing G06T3/4038
• CPC Class Codes: G06T 7/30 Determination of transform parameters for the alignment of images, i.e. image registration

Abstract

A method and a system for using tomosynthesis projection images of a patient'"'"'s breast to reconstruct slice tomosynthesis images such that anatomical structures that appear superimposed in a mammogram are at conforming locations in the reconstructed images.

Claims

1. A method comprising:

acquiring several 2D x-ray tomosynthesis projection images Tp of a patient'"'"'s breast taken at different angles of an imaging x-ray beam relative to the breast;

computer-processing the projection images Tp into reconstructed slice images Tr representing respective 3D slices of the breast;

said computer-processing comprising first reconstructing said projection images Tp into initial slice images Tr(i) in a first coordinate system and then computer-processing the initial slice images Tr(i) into a second, different coordinate system to generate said slice images Tr; and

selectively displaying said slice images Tr on a computer display unit.

2. A method as in claim 1 in which the pixels of said initial slice images Tr (i) represent voxels in the breast that are the same in size at least in planes to which the respective slices conform.

3. A method as in claim 2 in which different ones of said slice images Tr have pixels representing voxels differing in size at least in planes to which the respective slices conform.

4. A method as in claim 1 in which said initial slice images Tr(i) have the same pixel spacing.

5. A method as in claim 4 in which different ones of said slice images Tr have different pixel spacing.

6. An x-ray system comprising:

a data acquisition unit using x-rays emanating from an origin and an x-ray receptor acquiring several projection tomosynthesis images Tp of a patient'"'"'s breast taken at different angles of the x-rays relative to the breast;

an image reconstruction unit receiving the projection images Tp and reconstructing them into slice images Tr representing respective slices of the breast;

each of said slice images Tr comprising respective pixel values representing a respective array of pixels;

wherein the image reconstruction unit reconstructs said projection images Tp into initial slice images Tr(i) in a first coordinate system and then maps said initial slice images into said slice images Tr in a second, different coordinate system.

8. The system of claim 6 in which different slice images Tr have pixels representing voxels differing in size at least in planes to which the respective slices conform.

7. The system of 6 in which the pixels of said initial slice images Tr(i) represent voxels in the breast that are the same in size at least in planes to which the respective slices conform.

9. A method comprising:

obtaining slice images Tr representing respective 3D slices of the breast reconstructed through computer processing of several 2D x-ray tomosynthesis projection images Tp of a patient'"'"'s breast taken at different angles of an imaging x-ray beam relative to the breast;

at least a plurality of said 3D slices of the breast extending along planes parallel to each other;

each of said slice images Tr being a pixel image where the pixels represent respective volume elements of breast tissue;

wherein in said planes said volume elements differ in area between at least two of said slices of the patient'"'"'s breast; and

displaying at least one of said slice images Tr as pixel images on a computer display.

10. The method of claim 9 in which the pixels representing volume elements traversed by a given ray of a divergent imaging x-ray beam are at the same pixel position in each of a plurality of said slice images Tr.

11. The method of claim 10 in which the pixels representing volume elements traversed by a given ray are at the same pixel position in each of said slice images Tr.

13. The method of claim 9 in which the pixel spacing is the same in each of the displayed images Tr.

14. The method of claim 9 further comprising obtaining a mammogram of the breast and selectively displaying said mammogram concurrently with displaying of at least one of said slice images Tr.

15. The method of claim 14 in which said concurrent displaying comprises a superimposed display of said mammogram and at least one of said slice images Tr.

12. The method of 9 in which the pixel spacing is the same in a plurality of the displayed images Tr.

16. An image reconstruction and display system configured to carry out the steps of:

obtaining slice images Tr representing respective 3D slices of the breast reconstructed through computer processing of several 2D x-ray tomosynthesis projection images Tp of a patient'"'"'s breast taken at different angles of an imaging x-ray beam relative to the breast;

at least a plurality of said 3D slices of the breast extending along planes parallel to each other;

each of said slice images Tr being a pixel image where the pixels represent respective volume elements of breast tissue;

wherein in said planes said volume elements differ in area between at least two of said slices of the patient'"'"'s breast; and

displaying at least one of said slice images Tr as pixel images on a computer display.

17. The image reconstruction and display system of claim 16 in which the pixels representing volume elements traversed by a given ray of a divergent imaging x-ray beam are at the same pixel position in each of a plurality of said slice images Tr.

18. The image reconstruction and display system of claim 17 in which the pixels representing volume elements traversed by a given ray of a divergent imaging x-ray beam are at the same pixel position in each of said slice images Tr.

19. The image reconstruction and display system of claim 16 in which the pixel spacing is the same in a plurality of the displayed images Tr.

20. The image reconstruction and display system of claim 19 in which the pixel spacing is the same in each of the displayed images Tr.