System and method for accurate placement of a catheter tip in a patient

• US 8,715,195 B2
• Filed: 04/09/2008
• Issued: 05/06/2014
• Est. Priority Date: 04/11/2007
• Status: Active Grant

• Current Assignee: Elcam Medical Agricultural Cooperative Association Ltd
• Original Assignee: Elcam Medical Agricultural Cooperative Association Ltd
• Inventors: Ziv, David
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): CATINA, MICHAEL ANTHONY
• Application Number:
  US12/594,869
• Publication Number:
  US 20100049062A1
• Time in Patent Office: 2,218 Days
• Field of Search: 600/481, 600/485, 600/486, 600/488, 600500-507, 604/264, 604/523, 604/528
• US Class Current: 600/486
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02152 specially adapted for venous pressure
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 7/005 Detecting noise caused by implants, e.g. cardiac valves
• CPC Class Codes: A61M 2025/0002 with a pressure sensor at the distal end
• CPC Class Codes: A61M 25/0105 Steering means as part of the catheter or advancing means; Markers for positioning systems for detection of markers A61B

Abstract

A system for accurate placement of a catheter tip in a patient, the system including a catheter adapted for placement within a patient, the catheter having a tip at a distal end thereof and having a proximal end which is normally located outside of the patient, a pressure sensor adapted to sense pressure at the tip of the catheter and catheter tip placement location indicating circuitry operative in response to at least an output of the pressure sensor for indicating the location of the catheter tip in the patient.

Claims

1. A system for accurate placement of a catheter tip in a patient, the system comprising:

a catheter adapted for placement within a vein of a patient, the catheter having a tip at a distal end thereof and having a proximal end which is normally located outside of the patient;

a pressure sensor adapted to sense pressure within the vein of said patient at said tip of said catheter, said pressure sensor being adapted to sense a venous pressure waveform including at least one of a V pressure wave, generated by filling of the right atrium, and an A pressure wave, generated by contraction of the right atrium; and

catheter tip placement location indicating circuitry operative in response to at least an output of said pressure sensor and an ECG signal to provide an indication that said catheter tip is located in said patient at the junction of the superior vena cava (SVC) and the right atrium (RA),

an R wave of said ECG signal being employed by said catheter tip placement location indicating circuitry as a fiducial point with respect to which a propagation delay of said venous pressure waveform is measured, said catheter tip placement location indicating circuitry employing said propagation delay to provide said indication that said catheter tip is located at the junction of the superior vena cava (SVC) and the right atrium (RA).

2. A system for accurate placement of a catheter tip in a patient according to claim 1 and wherein said pressure sensor is adapted to sense a heart valve opening/closing signal which propagates at approximately 1540 m/sec. and to sense a pressure wave that is generating by the emptying, filling and contraction of the right atrium which propagates at approximately 2 m/sec.

3. A system for accurate placement of a catheter tip in a patient according to claim 2 and wherein the catheter tip placement location indicating circuitry is operative to distinguish between the heart valve opening/closing signal and the pressure wave that is generating by the emptying, filling and contraction of the right atrium.

4. A system for accurate placement of a catheter tip in a patient according to claim 2 and wherein the catheter tip placement location indicating circuitry is operative for indicating the location of said catheter tip in said patient on the basis of the time relationship of the heart valve opening/closing signal and the pressure wave that is generating by the emptying, filling and contraction of the right atrium sensed by said pressure sensor.

5. A system for accurate placement of a catheter tip in a patient according to claim 1 and wherein said pressure sensor is located at said catheter tip.

6. A system for accurate placement of a catheter tip in a patient according to claim 1 and wherein said pressure sensor is located at said proximal end of said catheter.

7. A system for accurate placement of a catheter tip in a patient according to claim 1 and wherein said indication is based on the change in successive measurements of a propagation delay in pressure waves measured by said pressure sensor.

8. A system for accurate placement of a catheter tip in a patient according to claim 1 and also comprising a computer and a monitor, said computer operative to provide, by displaying on said monitor, catheter tip insertion instructions based at least partially on an output from said catheter tip placement location indicating circuitry.

9. A method for accurate placement of a catheter tip in a patient, the method comprising:

placing a catheter within a vein of a patient, said catheter having a tip at a distal end thereof and having a proximal end which is normally located outside of the patient;

sensing pressure within the vein of said patient at said tip of said catheter, said sensing pressure comprising sensing a venous pressure waveform including at least one of a V pressure wave, generated by filling of the right atrium, and an A pressure wave, generated by contraction of the right atrium;

receiving an ECG signal;

measuring a propagation delay of said venous pressure waveform using a processor, said measuring comprising employing an R wave of said ECG signal as a fiducial point with respect to which said propagation delay is measured; and

employing said propagation delay to provide an indication that said catheter tip is located in said patient at the junction of the superior vena cava (SVC) and the right atrium (RA).

10. A method for accurate placement of a catheter tip in a patient according to claim 9 and wherein said sensing pressure comprises:

sensing a heart valve opening/closing signal which propagates at approximately 1540 m/sec.; and

sensing a pressure wave generated by the emptying, filling and contraction of the right atrium which propagates at approximately 2 msec.

11. A method for accurate placement of a catheter tip in a patient according to claim 10 and also comprising distinguishing between said heart valve opening/closing signal and said pressure wave.

12. A method for accurate placement of a catheter tip in a patient according to claim 11 and wherein said indicating comprises calculating a time relationship between said heart valve opening/closing signal and said pressure wave.

13. A method for accurate placement of a catheter tip in a patient according to claim 9 and also comprising displaying catheter tip insertion instructions on a monitor based at least partially on an output from said indicating.