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Balloon catheter systems for delivery of dry drug delivery vesicles to a vessel in the body

  • US 8,715,230 B2
  • Filed: 04/02/2013
  • Issued: 05/06/2014
  • Est. Priority Date: 12/30/2009
  • Status: Active Grant
First Claim
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1. A system for delivery of drugs or therapeutic agents to a blood vessel, said system comprising:

  • balloon catheter comprising a catheter body with a distal end adapted for insertion into the vasculature of a patient, a porous balloon disposed on the distal end, and a proximal end adapted for connection to a fluid source, and a lumen extending from the proximal end to the balloon;

    a storage chamber with a reservoir of dry drug delivery vesicles;

    an inflator;

    a suspension chamber in fluid communication with an inflator;

    a valve operable to selectively connect the suspension chamber to the storage chamber or the lumen of the catheter;

    wherein the inflator is operable to fill the storage chamber with fluid to reconstitute the dry drug delivery vesicles into a fluid suspension of drug delivery vesicles and draw the fluid suspension into the suspension chamber, when the valve is positioned to connect the storage chamber to the suspension chamber, and the inflator is operable to force the suspension from the suspension chamber through the catheter lumen and porous balloon to the blood vessel.

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