Bioerodible endoprostheses and methods of making the same
First Claim
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1. An endoprosthesis, comprising:
- a cathode region and an anode region between which a galvanic cell is formed when the endoprosthesis is implanted in the body, and the anode region is degraded by galvanic corrosion; and
a current controlling layer that erodes to control and limit an area of the anode region exposed to body fluid such that current density generated by the galvanic cell is maintained between ±
10 percent during degradation of between 5 percent to 50 percent by weight of the anode region.
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Abstract
A bioerodible endoprosthesis erodes by galvanic erosion that can provide, e.g., improved endothelialization and therapeutic effects.
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Citations
12 Claims
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1. An endoprosthesis, comprising:
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a cathode region and an anode region between which a galvanic cell is formed when the endoprosthesis is implanted in the body, and the anode region is degraded by galvanic corrosion; and a current controlling layer that erodes to control and limit an area of the anode region exposed to body fluid such that current density generated by the galvanic cell is maintained between ±
10 percent during degradation of between 5 percent to 50 percent by weight of the anode region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An erodible endoprosthesis, comprising:
a body including a relatively electronegative material and a relatively electropositive material between which a galvanic cell is formed, the body being formed of an alloy including the electronegative material and the electropositive material, the concentration of electronegative and electropositive material varying in the alloy along a length of the body, wherein concentrations of the electronegative and the electropositive materials are tailored along the length such that, when exposed to body fluid, a current density is generated and maintained between ±
10 percent during degradation of between 5 percent to 50 percent by weight of the endoprosthesis.- View Dependent Claims (12)
Specification