Strontium-apatite cement preparation cements formed therefrom, and use thereof

• US 8,715,410 B2
• Filed: 06/02/2010
• Issued: 05/06/2014
• Est. Priority Date: 06/07/2002
• Status: Expired due to Fees

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Wenz, Robert
• Primary Examiner(s): Koslow, Carol M
• Application Number:
  US12/792,526
• Publication Number:
  US 20100240593A1
• Time in Patent Office: 1,434 Days
• Field of Search: 106/690, 106/691, 623/23.62
• US Class Current: 106/690
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: C04B 14/26 Carbonates
• CPC Class Codes: C04B 2111/00836 for medical or dental applications
• CPC Class Codes: C04B 28/344 the phosphate binder being present in the starting composition solely as one or more phosphates

Abstract

Calcium-strontium-hydroxyphosphate (strontium-apatite-) cement preparations are described, comprising a powder mixture, which contains molar quantities of the components calcium (Ca), strontium (Sr) and phosphate (P) in the mixture in the ranges 1.00<Ca/P≦1.50 and 0<Sr/P<1.5, together with an alkali salt or an ammonium salt of phosphoric acid, and with water and/or an aqueous solution. The powder mixture particularly contains, as the Ca-component, Ca₃(PO₄)₂ (TCP), and as the Sr-component SrHPO₄ and/or Sr₃(PO₄)₂ and optionally additional SrCO₃. As the aqueous mixing solution for the formation of the strontium-apatite cement, an aqueous solution of an alkali salt or an ammonium salt of the phosphoric acid is suitable.

Claims

1. A cement system for augmenting bone, the system comprising:

a powder mixture component comprising a tricalcium orthophosphate and a strontium orthophosphate, wherein the molar ratio of calcium to phosphate is 1 to about 1.5, and a molar ratio of strontium to phosphate is not greater than about 1.5;

and an aqueous component comprising a solution of a salt of an orthophosphoric acid selected from the group consisting of an alkali salt, an ammonium salt and a combination thereof; and

wherein the powder and liquid each contain no more than trace amounts of magnesium ions.

2. The cement system for augmenting bone of claim 1, further comprising drugs of biological or pharmaceutical origin or a pharmacological and/or biologically active substance.

3. The cement system for augmenting bone of claim 2, wherein the drugs of biological or pharmaceutical origin comprise a drug from the series of bone morphogenic proteins.

4. The cement system for augmenting bone of claim 1, wherein the powder further comprises a substance in the form of granular particles which dissolves in an aqueous liquid component.

5. The cement system for augmenting bone of claim 4, wherein the granular particles are about 10 μ

m to about 300 μ

m.

6. The cement system for augmenting bone of claim 1, wherein the salt of an orthophosphoric acid is a primary or secondary sodium or potassium salt.