Tissue site markers for in vivo imaging

• US 8,718,745 B2
• Filed: 05/25/2010
• Issued: 05/06/2014
• Est. Priority Date: 11/20/2000
• Status: Expired due to Fees

• Current Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Original Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Inventors: Burbank, Fred H., Lubock, Paul, Jones, Michael L., Quick, Richard L., Louw, Frank R., DeSantis, Stephen A.
• Primary Examiner(s): Jung, Unsu
• Assistant Examiner(s): FISHER, MICHAEL NAPOLEON
• Application Number:
  US12/787,177
• Publication Number:
  US 20100298698A1
• Time in Patent Office: 1,442 Days
• Field of Search: 600/325, 600/332, 600/354, 600/357, 600/375, 600/414, 600/423, 600/426, 600/431, 600/464, 600/566, 600/567, 604/44, 604/59, 606/14, 606/275, 606/276, 606/277
• US Class Current: 600/426
• CPC Class Codes: A61B 2090/08021 of the patient or his organs
• CPC Class Codes: A61B 2090/3908 Soft tissue, e.g. breast tissue
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 2090/3987 Applicators for implanting markers
• CPC Class Codes: A61B 2090/3991 having specific anchoring means to fixate the marker to the tissue, e.g. hooks
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

An intracorporeal site marker has high ultrasound reflectivity, presents a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The biopsy site marker may include features to fix the marker to the biopsy site so as to resist migration from the biopsy cavity.

Claims

1. An intracorporeal site marker for marking a selected site within tissue of a patient'"'"'s body, comprising an ultrasound detectable body having a multi-planar surface contour which includes a plurality of distinct recessed planar surface portions that define a plurality of exposed recessed exterior boundaries having a high contrast in acoustical impedance when the marker is placed in tissue of the selected site, so as to reflect ultrasound during ultrasound imaging, and which is recognizably artificial when the marker is subject to ultrasound or X-ray imaging, so as to be readily distinguishable from biological features within the tissue site.

2. The intracorporeal site marker of claim 1 wherein the ultrasound detectable body is formed from a sintered metal.

3. The intracorporeal site marker of claim 1, wherein the ultrasound detectable body is formed from a porous metal.

4. The intracorporeal site marker of claim 1, wherein the plurality of exposed recessed exterior boundaries are configured to culminate at a recessed apex.

5. The intracorporeal site marker of claim 1, wherein the ultrasound detectable body includes a plurality of multi-planar surface contours, each of the plurality of multi-planar surface contours having a plurality of distinct recessed planar surface portions.

6. The intracorporeal site marker of claim 1, wherein the ultrasound detectable body has a cruciform cross-section shape having a plurality of fin-like portions that are joined at a central longitudinal axis.

7. The intracorporeal site marker of claim 6, comprising a plurality of medial web portions, with each medial web portion configured to span laterally and join between an adjacent pair of the plurality of fin-like portions.

8. An intracorporeal site marker for marking a selected site within tissue of a patient'"'"'s body, comprising an ultrasound detectable body having a multi-planar surface contour which includes a plurality of distinct recessed planar surface portions that culminate at a recessed apex, the multi-planar surface contour being configured to define a plurality of boundaries having a high contrast in acoustical impedance when the marker is placed in tissue of the selected site, so as to reflect ultrasound during ultrasound imaging, and which is recognizably artificial when the marker is subject to ultrasound or X-ray imaging, so as to be readily distinguishable from biological features within the tissue site, and, an encapsulation portion that surrounds the entirety of the ultrasound detectable body.

9. The intracorporeal site marker of claim 8, further comprising an adhesive component formed on an external surface of the encapsulation portion.

10. The intracorporeal site marker of claim 9, wherein the adhesive component is a coating layer formed on the external surface of the encapsulation portion.

11. An intracorporeal site marker for marking a selected site within tissue of a patient'"'"'s body, comprising an ultrasound detectable body having at least one multi-planar surface contour which includes a plurality of distinct recessed planar surface portions that culminate at a recessed apex, the multi-planar surface contour being configured to define a plurality of boundaries having a high contrast in acoustical impedance when the marker is placed in tissue of the selected site, so as to reflect ultrasound during ultrasound imaging, and which is recognizably artificial when the marker is subject to ultrasound or X-ray imaging, so as to be readily distinguishable from biological features within the tissue site, and, an encapsulation portion that surrounds only a portion of the ultrasound detectable body.

12. The intracorporeal site marker of claim 11, further comprising an adhesive component formed on an external surface of the encapsulation portion.

13. The intracorporeal site marker of claim 12, wherein the adhesive component is a coating layer formed on the external surface of the encapsulation portion.

14. An intracorporeal site marker for marking a selected site within tissue of a patient'"'"'s body, comprising an ultrasound detectable body having a multi-planar surface contour that is X-shaped along a longitudinal axis and which includes a plurality of distinct recessed planar surface portions that culminate at a recessed apex adjacent the longitudinal axis, the multi-planar surface contour being configured to define a plurality of boundaries having a high contrast in acoustical impedance when the marker is placed in tissue of the selected site, so as to reflect ultrasound during ultrasound imaging, and which is recognizably artificial when the marker is subject to ultrasound or X-ray imaging, so as to be readily distinguishable from biological features within the tissue site.

15. The intracorporeal site marker of claim 14, wherein the X-shaped contour and longitudinal axis is intersected by a planar web portion to define four recessed multi-planar surface contours with each of the four recessed multi-planar surface contours having a plurality of distinct recessed planar surface portions that culminate at a respective recessed apex adjacent the longitudinal axis.