Heart failure decompensation prediction based on cardiac rhythm
First Claim
1. A method of detecting an impending cardiac decompensation of a patient, the method comprising:
- measuring an electrocardiogram signal of the patient;
determining an incidence of cardiac arrhythmias from the electrocardiogram signal;
measuring a bioimpedance of the patient;
determining from the measured bioimpedance a measure of a tissue hydration of the patient; and
determining a risk of impending decompensation in response to a combination of the measured tissue hydration and the incidence of cardiac arrhythmias.
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Accused Products
Abstract
Systems and methods of detecting an impending cardiac decompensation of a patient measure an electrocardiogram signal of the patient. An incidence of cardiac arrhythmias is determined from the electrocardiogram signal. A risk of impending decompensation is determined in response to the incidence of cardiac arrhythmias. In many embodiments, the impending decompensation can be detected early enough to avoid, or at least delay, the impending decompensation, such that patient trauma and/or expensive ICU care can be avoided. Although embodiments make specific reference to monitoring electrocardiogram and other physiological signals with an adherent patch, the system methods and devices are applicable to many applications in which physiological monitoring is used, for example wireless physiological monitoring with implanted sensors for extended periods.
936 Citations
42 Claims
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1. A method of detecting an impending cardiac decompensation of a patient, the method comprising:
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measuring an electrocardiogram signal of the patient; determining an incidence of cardiac arrhythmias from the electrocardiogram signal; measuring a bioimpedance of the patient; determining from the measured bioimpedance a measure of a tissue hydration of the patient; and determining a risk of impending decompensation in response to a combination of the measured tissue hydration and the incidence of cardiac arrhythmias. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A system to detect impending cardiac decompensation of a patient, the system comprising:
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an adherent patch comprising a breathable tape, electrodes, gel, circuitry to measure an electrocardiogram signal of the patient and a bioimpedance of the patient, and wireless communication circuitry, wherein the adherent patch is arranged to adhere continuously to the patient for at least one week and measure the electrocardiogram signal and the bioimpedance for the at least one week; an intermediate device configured to wirelessly receive information from the adherent patch and to transmit information to a remote site; and a processor system at the remote site, the processor system comprising a tangible medium in communication with the circuitry to receive the information transmitted from the intermediate device, the processor system configured to determine a risk of impending decompensation in response to an incidence of cardiac arrhythmias and a tissue hydration signal determined from the bioimpedance, wherein the incidence of cardiac arrhythmias is determined by the adherent patch, by the intermediate device, or by the processor system at the remote site. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A system to detect impending cardiac decompensation of a patient, the system comprising:
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circuitry to measure an electrocardiogram signal of the patient; circuitry to measure a bioimpedance of the patient and to determine from the measured bioimpedance a measure of a tissue hydration of the patient; and one or more processors comprising tangible media in communication with the circuitry, the one or more processors configured to determine an incidence of cardiac arrhythmias from the electrocardiogram signal and determine a risk of impending decompensation in response to a combination of the tissue hydration and the incidence of cardiac arrhythmias. - View Dependent Claims (38, 39, 40)
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41. A computer-readable storage medium comprising a set of instructions for a computer system to evaluate a risk of an impending cardiac decompensation of a patient, the set of instructions comprising:
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an input routine operatively associated with a source of electrocardiogram data from the patient and bioimpedance data from the patient; a run routine to determine form the bioimpedance data a tissue hydration data of the patient, and to determine a risk of the impending cardiac decompensation of the patient with the source of electrocardiogram data and tissue hydration data; and an output routine providing the risk of the impending decompensation available for external use outside the computer system. - View Dependent Claims (42)
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Specification