Vagal stimulation

• US 8,718,763 B2
• Filed: 01/19/2012
• Issued: 05/06/2014
• Est. Priority Date: 01/19/2011
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Zhou, Xiaohong, Stadler, Robert, Cornelussen, Richard N. M., Kornet, Lilian, Ziegler, Paul D., Kleckner, Karen J., Della Scala, Alberto
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Stice, Paula J
• Application Number:
  US13/353,824
• Publication Number:
  US 20120185008A1
• Time in Patent Office: 838 Days
• Field of Search: None
• US Class Current: 607/14
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362

Abstract

The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

Claims

1. A device for providing vagal stimulation comprising:

monitoring apparatus configured to monitor physiological parameters of a patient, wherein the monitoring apparatus comprises at least one electrode configured to monitor the electrical activity of the patient'"'"'s heart;

a sensing module operably coupled to the monitoring apparatus and configured to receive the monitored physiological parameters;

a therapy delivery module configured to deliver electrical stimulation to the patient'"'"'s vagus nerve; and

a control module operably coupled to the sensing module and to the therapy delivery module and configured to;

detect a supraventricular tachycardia using the monitored physiological parameters,

initiate delivery of electrical stimulation to the patient'"'"'s vagus nerve upon detecting the supraventricular tachycardia,

analyze the monitored physiological parameters for termination criteria after initiating delivery of electrical stimulation to the patient'"'"'s vagus nerve, wherein analyzing the monitored physiological parameters comprises determining whether the R-R intervals within the electrical activity of the patient'"'"'s heart have increased, and

terminate the delivery of electrical stimulation to the patient'"'"'s vagus nerve if the R-R intervals within the electrical activity of the patient'"'"'s heart have not increased.

2. The device of claim 1, wherein determining whether the R-R intervals within the electrical activity of the patient'"'"'s heart have increased comprises comparing an average R-R interval monitored after delivering electrical stimulation to the patient'"'"'s vagus nerve to a median R-R interval monitored before delivering electrical stimulation to the patient'"'"'s vagus nerve.

3. The device of claim 1, wherein the control module is further configured to terminate the delivery of electrical stimulation to the patient'"'"'s vagus nerve after a selected time period has elapsed.

4. The device of claim 1, wherein the control module is further configured to prevent the delivery of electrical stimulation to the patient'"'"'s vagus nerve for a selected time period after terminating the delivery of electrical stimulation to the patient'"'"'s vagus nerve.

5. The device of claim 1, wherein analyzing the monitored physiological parameters further comprises determining whether the P-R intervals within the electrical activity of the patient'"'"'s heart have increased, and wherein the control module is further configured to terminate the delivery of electrical stimulation to the patient'"'"'s vagus nerve if the P-R intervals within the electrical activity of the patient'"'"'s heart have not increased.

6. The device of claim 1, wherein analyzing the monitored physiological parameters further comprises determining whether the patient'"'"'s cardiac condition is worsening after the delivery of electrical stimulation to the patient'"'"'s vagus nerve, and wherein the control module is further configured to terminate the delivery of electrical stimulation to the patient'"'"'s vagus nerve if the patient'"'"'s cardiac condition is worsening.

7. The device of claim 6, wherein determining whether the patient'"'"'s cardiac condition is worsening comprises determining whether the monitored physiological parameters of the patient indicate at least one of atrial fibrillation, ventricular arrhythmia, mechanical functional deterioration, and syncope, and wherein terminating the delivery of electrical stimulation to the patient'"'"'s vagus nerve if the patient'"'"'s cardiac condition is worsening comprises terminating the delivery of electrical stimulation to the patient'"'"'s vagus nerve if the monitored physiological parameters of the patient indicate at least one of atrial fibrillation, ventricular arrhythmia, mechanical functional deterioration, and syncope.

8. The device of claim 1, wherein the control module is further configured to control the delivery of electrical stimulation to the patient'"'"'s vagus nerve to be synchronized to blanking periods associated with either of the P-waves or the R-waves within the electrical activity of the patient'"'"'s heart.

9. A method of providing vagal stimulation comprising:

monitoring physiological parameters of a patient, wherein the physiological parameters comprise the electrical activity of the patient'"'"'s heart;

detecting a supraventricular tachycardia using the monitored physiological parameters;

initiating delivery of electrical stimulation to the patient'"'"'s vagus nerve upon detecting the supraventricular tachycardia;

analyzing the monitored physiological parameters for termination criteria after initiating delivery of electrical stimulation to the patient'"'"'s vagus nerve, wherein analyzing the monitored physiological parameters comprises;

determining whether the R-R intervals of the electrical activity of the patient'"'"'s heart have increased, and

determining whether the patient'"'"'s cardiac condition is worsening delivering electrical stimulation to the patient'"'"'s vagus nerve; and

terminating the delivery of electrical stimulation to the patient'"'"'s vagus nerve if the R-R intervals within the electrical activity of the patient'"'"'s heart have not increased or the patient'"'"'s cardiac condition is worsening.

10. The method of claim 9, wherein determining whether the R-R intervals of the electrical activity of the patient'"'"'s heart have increased comprises comparing an average R-R interval monitored after delivering electrical stimulation to the patient'"'"'s vagus nerve to a median R-R interval monitored before delivering electrical stimulation to the patient'"'"'s vagus nerve.

11. The method of claim 10, wherein the method further comprises terminating the delivery of electrical stimulation to the patient'"'"'s vagus nerve after a selected time period has elapsed.

12. The method of claim 11, wherein the method further comprises preventing delivery of electrical stimulation to the patient'"'"'s vagus nerve for a selected time period after terminating the delivery of electrical stimulation to the patient'"'"'s vagus nerve.

13. The method of claim 12, wherein analyzing the monitored physiological parameters further comprises determining whether the P-R intervals of the electrical activity of the patient'"'"'s heart have increased, and

wherein the method further comprises terminating the delivery of electrical stimulation to the patient'"'"'s vagus nerve if the P-R intervals of the electrical activity of the patient'"'"'s heart have not increased.

14. The method of claim 11, wherein determining whether the patient'"'"'s cardiac condition is worsening comprises determining whether the monitored physiological parameters of the patient indicate at least one of atrial fibrillation, ventricular arrhythmia, mechanical functional deterioration, and syncope, and wherein terminating the delivery of electrical stimulation to the patient'"'"'s vagus nerve if the patient'"'"'s cardiac condition is worsening comprises terminating the delivery of electrical stimulation to the patient'"'"'s vagus nerve if the monitored physiological parameters of the patient indicate at least one of atrial fibrillation, ventricular arrhythmia, mechanical functional deterioration, and syncope.

15. The method of claim 9, wherein the delivery of electrical stimulation to the patient'"'"'s vagus nerve is synchronized to blanking periods associated with either of the P-waves or the R-waves within the electrical activity of the patient'"'"'s heart.