Cardiac function management integrating cardiac contractility modulation

• US 8,718,764 B2
• Filed: 09/16/2009
• Issued: 05/06/2014
• Est. Priority Date: 09/16/2008
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Stahmann, Jeffrey E.
• Primary Examiner(s): Koharski, Christopher
• Assistant Examiner(s): VOORHEES, CATHERINE M
• Application Number:
  US12/561,137
• Publication Number:
  US 20100069984A1
• Time in Patent Office: 1,693 Days
• Field of Search: 607 2- 5, 607/9, 607 17- 19, 607/22, 607/25, 607/27
• US Class Current: 607/17
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3686 configured for selecting the electrode configuration on a lead A61N1/3688 takes precedence
• CPC Class Codes: A61N 1/37 Monitoring; Protecting
• CPC Class Codes: A61N 1/3706 Pacemaker parameters stimulation threshold A61N1/371
• CPC Class Codes: A61N 1/3708 for power depletion
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

An implantable cardiac rhythm/function management system integrates cardiac contractility modulation (CCM) and one or more other therapies, such as to preserve device safety, improve efficacy, enhance sensing and detection, or enhance therapy effectiveness and delivery. Examples of the one or more other therapies can include pacing, defibrillation/cardioversion, cardiac resynchronization therapy (CRT), or neurostimulation.

Claims

1. An implantable cardiac function management device comprising:

a cardiac contractility modulation (CCM) therapy circuit configured to deliver a CCM therapy including a non-stimulatory electrical energy during a refractory period of the heart;

a physiologic sensor circuit configured to sense information about a renal parameter;

a neural stimulation circuit configured to deliver neural stimulation therapy; and

a controller circuit, coupled to the CCM therapy circuit, the physiologic sensor circuit, and the neural stimulation circuit, the controller circuit configured to;

obtain or provide information about the CCM therapy;

obtain or provide information about the neural stimulation therapy; and

adjust at least one of the CCM therapy delivered by the CCM therapy circuit or the neural stimulation therapy delivered by the neural stimulation circuit using information about the other of the CCM therapy or the neural stimulation therapy and using the information about the renal parameter.

2. The device of claim 1, wherein the controller circuit is configured to use the information about the renal parameter to coordinate the CCM therapy circuit to adjust at least one of CCM energy, CCM delivery timing, CCM delivery location, or CCM electrode configuration.

3. The device of claim 1, wherein the physiologic sensor circuit includes an electrolyte sensor configured to detect an indication of a measure of at least one of:

potassium, sodium, calcium, chloride, or bicarbonate.

4. The device of claim 3, wherein the controller circuit is configured to use information about the measure of the least one of potassium, sodium, calcium, chloride, or bicarbonate, to coordinate the CCM therapy circuit to adjust at least one of CCM energy, CCM delivery timing, CCM delivery location, or CCM electrode configuration.

5. The device of claim 1, wherein the physiologic sensor circuit is configured to detect an indication of a measure of at least one of:

blood urea nitrogen, serum creatinine, or glomerular filtration rate.

6. The device of claim 5, wherein the controller circuit is configured to use information about the measure of the at least one of:

blood urea nitrogen, serum creatinine, or glomerular filtration rate, to coordinate the CCM therapy circuit to adjust at least one of CCM energy, CCM delivery timing, CCM delivery location, or CCM electrode configuration.

7. The device of claim 1, comprising a neural sensor configured to sense a neural signal.

8. The device of claim 7, wherein the controller circuit is configured to use information about the neural signal to coordinate the CCM therapy circuit to adjust at least one of CCM energy, CCM delivery timing, CCM delivery location, or CCM electrode configuration.

9. The device of claim 7, wherein the neural sensor is configured to sense a neural signal from a vagal nerve;

and

wherein the neural signal from the vagal nerve includes an indication of one of an increase or a decrease in vagal nerve activity.

10. The device of claim 9, wherein the controller circuit is configured such that, when the neural signal indicates an increase in vagal nerve activity, the controller circuit is configured to coordinate the CCM therapy circuit to increase at least one of CCM energy or frequency of CCM delivery.

11. The device of claim 7, wherein the neural sensor is configured to monitor at least one of sympathetic nerve activity or parasympathetic nerve activity;

and

wherein the neural signal includes an indication of at least one of;

an increase in sympathetic nerve activity, a decrease in sympathetic nerve activity, an increase in parasympathetic nerve activity, or a decrease in parasympathetic nerve activity.

12. The device of claim 11, wherein the controller circuit is configured such that, when the neural signal indicates at least one of an increase in parasympathetic nerve activity or a decrease in sympathetic nerve activity, the controller circuit is configured to coordinate the CCM therapy circuit to increase at least one of CCM energy or frequency of CCM delivery.

13. The device of claim 11, wherein the controller circuit is configured such that, when the neural signal indicates at least one of an increase in sympathetic nerve activity or a decrease in parasympathetic nerve activity, the controller circuit is configured to coordinate the CCM therapy circuit to decrease at least one of CCM energy or frequency of CCM delivery.

14. The device of claim 1, wherein the controller circuit is configured to use information about the neural stimulation therapy to coordinate the CCM therapy circuit to adjust at least one of CCM energy, CCM delivery timing, CCM delivery location, or CCM electrode configuration.

15. The device of claim 1, wherein the controller circuit is configured to use the information about the renal parameter to coordinate the CCM therapy circuit to adjust at least one of CCM energy, CCM delivery timing, CCM delivery location, or CCM electrode configuration.

16. An implantable cardiac function management device comprising:

a cardiac contractility modulation (CCM) therapy circuit configured to deliver a CCM therapy including a non-stimulatory electrical energy during a refractory period of the heart;

a physiologic sensor circuit configured to sense a physiologic parameter; and

a controller circuit, coupled to the CCM therapy circuit and the physiologic sensor circuit, the controller circuit configured to obtain or provide information about the CCM therapy and information about the sensed physiologic parameter, the controller circuit configured to coordinate the CCM therapy circuit to adjust the CCM therapy using information about the sensed physiologic parameter;

wherein the physiologic sensor circuit is configured to sense an indication of a measure of a renal parameter; and

wherein the controller circuit is configured to use the information about the sensed physiologic parameter including information about the renal parameter to coordinate the CCM therapy circuit to adjust at least one of CCM energy, CCM delivery timing, CCM delivery location, or CCM electrode configuration;

wherein the physiologic sensor circuit includes an electrolyte sensor configured to detect an indication of a measure of at least one of;

potassium, sodium, calcium, chloride, or bicarbonate; and

wherein the controller circuit is configured to use information about the measure of the least one of potassium, sodium, calcium, chloride, or bicarbonate, to coordinate the CCM therapy circuit to adjust at least one of CCM energy, CCM delivery timing, CCM delivery location, or CCM electrode configuration;

wherein the physiologic sensor circuit is configured to detect an indication of a measure of at least one of;

blood urea nitrogen, serum creatinine, or glomerular filtration rate; and

wherein the controller circuit is configured to use information about the measure of the at least one of;

blood urea nitrogen, serum creatinine, or glomerular filtration rate, to coordinate the CCM therapy circuit to adjust at least one of CCM energy, CCM delivery timing, CCM delivery location, or CCM electrode configuration;

wherein the physiologic sensor circuit includes a neural sensor configured to sense a neural signal; and

wherein the controller circuit is configured to use information about the neural signal to coordinate the CCM therapy circuit to adjust at least one of CCM energy, CCM delivery timing, CCM delivery location, or CCM electrode configuration; and

comprising a neural stimulation circuit configured to deliver neural stimulation therapy;

wherein the controller circuit is configured to coordinate adjustment of at least one of the CCM therapy delivered by the CCM therapy circuit or the neural stimulation therapy delivered by the neural stimulation circuit using information about the other of the CCM therapy or the neural stimulation therapy; and

wherein the controller circuit is configured to coordinate adjustment of at least one of the CCM therapy or the neural stimulation therapy using information about the sensed physiologic parameter.