Penetrating electrodes for retinal stimulation

• US 8,718,784 B2
• Filed: 01/14/2010
• Issued: 05/06/2014
• Est. Priority Date: 01/14/2010
• Status: Active Grant

• Current Assignee: Nano-Retina Inc.
• Original Assignee: Nano-Retina Inc.
• Inventors: Gefen, Ra'anan, Saini, Rahul
• Primary Examiner(s): BEHRINGER, LUTHER G
• Application Number:
  US12/687,509
• Publication Number:
  US 20110172736A1
• Time in Patent Office: 1,573 Days
• Field of Search: 607/53
• US Class Current: 607/54
• CPC Class Codes: A61N 1/0543 Retinal electrodes

Abstract

Apparatus configured for implantation in a body of a subject is provided. The apparatus includes a support substrate, and at least 500 electrodes protruding at least 50 um from the support substrate, each electrode having (a) a distal tip, (b) an electrically-exposed tip portion, and (c) a cross-section of 50-1500 um2, 20 um from the distal tip. Other embodiments are also described.

Claims

1. An apparatus configured for implantation in a body of a subject, comprising:

a support substrate; and

at least 500 electrodes protruding at least 50 um from the support substrate, each electrode having (a) a distal tip, (b) an electrically-exposed tip portion, (c) an electrically-insulated body portion, proximal to the electrically-exposed tip portion, and (d) a cross-section of 50-200 um², at a site 20 um from the distal tip,

wherein the electrically-exposed tip portion of each electrode and the electrically-insulated body portion of each electrode are configured to penetrate retinal tissue of an eye of the subject, and

wherein each electrode is less than 600 um in length.

2. The apparatus according to claim 1, wherein each electrode tip has a rough surface.

3. The apparatus according to claim 1, wherein the retinal tissue of the subject includes a retinal bipolar cell layer of the subject, and wherein the tips are configured to penetrate the retinal bipolar cell layer.

4. The apparatus according to claim 1, wherein the tissue of the subject includes a retinal ganglion cell layer of the subject, and wherein the tips are configured to penetrate the retinal ganglion cell layer.

5. The apparatus according to claim 1, wherein the electrically-exposed tip portion of each electrode is 50-100 um in length.

6. The apparatus according to claim 1, wherein each distal tip has a radius of curvature of 0.5-5 um.

7. The apparatus according to claim 1, wherein the radius of curvature of the distal tips is 1-3 um.

8. The apparatus according to claim 1, wherein a distance from the substrate to the distal tip of each electrode is 200-500 um.

9. The apparatus according to claim 1, wherein the distal tip of the tips of the electrodes have an average distance from the support substrate of 50-150 um.

10. The apparatus according to claim 1, wherein the support substrate is generally flexible.

11. The apparatus according to claim 1, wherein the tips of the electrodes together define a convex curved surface having a radius of curvature that is 6-15 mm.

12. The apparatus according to claim 1, further comprising at least 100 surface electrodes, and wherein the protruding electrodes are shaped to define respective tips having rough surfaces.

13. The apparatus according to claim 12, wherein the surface electrodes are configured to function as return electrodes.

14. The apparatus according to claim 1, wherein the at least 500 electrodes are arranged in at least 10 clusters of three or more electrodes, and wherein:

at least some of the electrodes in each cluster are configured to drive respective currents into the tissue of the subject, and

the current driven by each electrode in the cluster is returned via an electrode in the cluster that serves as a common return electrode for the other electrodes in the cluster.

15. The apparatus according to claim 14, wherein at least some of the clusters comprise fewer than six electrodes.

16. The apparatus according to claim 1, wherein a spatial density of the electrodes is 100-400 electrodes per mm².

17. The apparatus according to claim 1, wherein the electrically-insulated body portion of each electrode has a cross section of 59-942um², midway along the electrically-insulated body portion of the electrode.

18. The apparatus according to claim 3, wherein the retinal tissue of the subject further includes a retinal ganglion cell layer of the subject, and wherein the electrically-insulated body portion of each electrode is configured to penetrate the retinal ganglion cell layer.

19. A method for retinal stimulation comprising:

identifying a subject as suffering from a retinal disease;

in response to identifying the subject, implanting in an eye of the subject an apparatus including;

a support substrate; and

at least 500 electrodes protruding at least 50um from the support substrate, each electrode having (a) a distal tip, (b) an electrically-exposed tip portion, (c) an electrically-insulated body portion, proximal to the electrically-exposed tip portion, (d) a length of less than 600 um and (e) a cross-section of 50-200 um², at a site 20um from the distal tip; and

positioning the apparatus such that the electrically-exposed tip portion of each electrode and the electrically-insulated body portion of each electrode penetrate retinal tissue of the eye of the subject.