Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors
First Claim
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1. A computer implemented method for detecting early signal attenuation in an analyte sensor, comprising:
- receiving a first plurality of analyte sensor related signals within a first predetermined time period after insertion of an analyte sensor into a user, wherein the first predetermined time period occurs within the first 24 hours of insertion;
determining a probability of early signal attenuation associated with the analyte sensor based at least in part on the first plurality of analyte sensor related signals;
receiving a second plurality of analyte sensor related signals during a second predetermined time period, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time;
receiving a reference analyte measurement during the second predetermined time period;
determining a sensitivity of the analyte sensor based on the second plurality of analyte sensor related signals and the reference analyte measurement;
determining a sensitivity ratio based on the determined sensitivity of the analyte sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the analyte sensor is manufactured;
verifying a presence of early signal attenuation when the determined sensitivity ratio is less than a first predetermined threshold level; and
generating a first output signal with a processor associated with the verification of the presence of early signal attenuation.
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Abstract
Method, system and computer program product for providing real time detection of analyte sensor sensitivity decline is continuous glucose monitoring systems are provided.
669 Citations
20 Claims
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1. A computer implemented method for detecting early signal attenuation in an analyte sensor, comprising:
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receiving a first plurality of analyte sensor related signals within a first predetermined time period after insertion of an analyte sensor into a user, wherein the first predetermined time period occurs within the first 24 hours of insertion; determining a probability of early signal attenuation associated with the analyte sensor based at least in part on the first plurality of analyte sensor related signals; receiving a second plurality of analyte sensor related signals during a second predetermined time period, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time; receiving a reference analyte measurement during the second predetermined time period; determining a sensitivity of the analyte sensor based on the second plurality of analyte sensor related signals and the reference analyte measurement; determining a sensitivity ratio based on the determined sensitivity of the analyte sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the analyte sensor is manufactured; verifying a presence of early signal attenuation when the determined sensitivity ratio is less than a first predetermined threshold level; and generating a first output signal with a processor associated with the verification of the presence of early signal attenuation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An apparatus, comprising:
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a data storage unit; and a processing unit operatively coupled to the data storage unit configured to receive a first plurality of analyte sensor related signals within a first predetermined time period after insertion of an analyte sensor into a user, wherein the first predetermined time period occurs within the first 24 hours of insertion, determine a probability of early signal attenuation associated with the analyte sensor based at least in part on the first plurality of analyte sensor related signals, receive a second plurality of analyte sensor related signals during a second predetermined time period, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time, receive a reference analyte measurement during the second predetermined time period, determine a sensitivity of the analyte sensor based on the second plurality of analyte sensor related signals and the reference analyte measurement, determine a sensitivity ratio based on the determined sensitivity of the analyte sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the analyte sensor is manufactured, verify a presence of early signal attenuation when the determined sensitivity ratio is less than a first predetermined threshold level, and generate a first output signal associated with the verification of the presence of early signal attenuation. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A system for detecting early signal attenuation in an analyte sensor, comprising:
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an analyte sensor for transcutaneous positioning through a skin layer of a user; and a data processing device operatively coupled to the analyte sensor, the data processing device configured to receive a first plurality of analyte sensor related signals within a first predetermined time period after insertion of the analyte sensor into the user, wherein the first predetermined time period occurs within the first 24 hours of insertion, determine a probability of early signal attenuation associated with the analyte sensor based at least in part on the first plurality of analyte sensor related signals, receive a second plurality of analyte sensor related signals during a second predetermined time period, wherein the second predetermined time period is offset from the first predetermined time period by a predetermined offset time, receive a reference analyte measurement during the second predetermined time period, determine a sensitivity of the analyte sensor based on the second plurality of analyte sensor related signals and the reference analyte measurement, determine a sensitivity ratio based on the determined sensitivity of the analyte sensor divided by a nominal sensitivity, the nominal sensitivity determined at the time the analyte sensor is manufactured, verify a presence of early signal attenuation when the determined sensitivity ratio is less than a first predetermined threshold level, and generate a first output signal associated with the verification of the presence of early signal attenuation.
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Specification