Laboratory instrumentation information management and control network

• US 8,719,053 B2
• Filed: 07/16/2004
• Issued: 05/06/2014
• Est. Priority Date: 07/17/2003
• Status: Active Grant

• Current Assignee: Ventana Medical Systems Incorporated (Roche Holding AG)
• Original Assignee: Ventana Medical Systems Incorporated (Roche Holding AG)
• Inventors: Showalter, Wayne, Larson, Alain L.
• Primary Examiner(s): Lubin, Valerie
• Assistant Examiner(s): Reyes, Reginald R
• Application Number:
  US10/893,725
• Publication Number:
  US 20050038676A1
• Time in Patent Office: 3,581 Days
• Field of Search: 705/3, 3/3
• US Class Current: 705/3
• CPC Class Codes: G01N 2035/00881 network configurations
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers
• CPC Class Codes: G06Q 10/06 Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
• CPC Class Codes: G06Q 10/10 Office automation; Time management
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 30/20 for handling medical images, e.g. DICOM, HL7 or PACS
• CPC Class Codes: G16H 40/40 for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

An interface point network (IPN) and a method for communication with a laboratory information system using an IPN, wherein the IPN includes at least one host computer in communication with at least one laboratory instrument, the laboratory information system and an interface point server in communication with the host computer and the laboratory information system, the interface point server being configured to function as a communication interface between the host computer and the laboratory information system in a manner responsive to a predetermined communication protocol.

Claims

1. A laboratory instrument information management and control apparatus, comprising:

a Laboratory Information System (LIS) configured to manage patient and laboratory information;

a plurality of laboratory instruments configured to run anatomical pathology tests including automated staining of a sample relating to at least one patient;

a plurality of host computers, wherein each of said plurality of host computers is in communication with a portion of said plurality of laboratory instruments;

an interface point server (IPS) in communication with said plurality of host computers and said LIS, said interface point server configured to function as a communication interface between said plurality of host computers and said LIS in a manner responsive to a predetermined communication protocol, and said IPS comprising a first level interface for data communication and control between said LIS and said IPS, and said IPS comprising a second level interface for data communication and control between said plurality of host computers and said IPS, wherein said first level interface and said second level interface are software interfaces, each of said plurality of host computers including host data and being independently configured with data sharing enabled or disabled, said second level interface facilitating replication of data elements shared between said plurality of host computers, said data elements that are shared being stored in a data element storage of said IPS, wherein said second level interface facilitates communicating an update, by a first of said plurality of host computers to a first of said data elements that are shared, to a second of said plurality of host computers sharing said first data element; and

wherein a first of the plurality of host computers includes a computer readable medium comprising code stored thereon for;

determining, by said first host computer that said first host computer requires use of a reagent whereby, in order for the first host computer to use the reagent, the first host computer requires ownership of a second data element associated with the reagent;

sending, by said first host computer to each other host computer of the plurality of host computers, a request requesting ownership of the second data element; and

wherein each other host computer of the plurality of host computers includes a computer readable medium comprising code stored thereon for;

receiving, at said each other host computer, the request from the first host computer;

determining, in accordance with information of a data element database of said each other host computer, whether said each other host computer currently owns the second data element and, if so, whether said second data element is locked; and

responsive to determining that said each other host computer is current owner of the second data element and the second data element is not locked, updating the data element database of said each other host computer to indicate the first host computer as current owner of the second data element rather than said each other host computer, and sending, by said each other host computer to the first host computer, a message indicating that the first host computer is current owner of the second data element thereby indicating the first host computer as current owner of the reagent associated the second data element.

2. The laboratory instrument information management and control apparatus of claim 1 wherein said plurality of laboratory instruments comprises at least two automated slide staining systems, and said second level interface of said IPS communicates with one of the plurality of host computers for managing data communication and control between said at least two automated slide staining systems and said IPS, and said second level interface of said IPS communicates with said one host computer for managing data communication and control among said at least two automated slide staining systems.

3. The laboratory instrument information management and control apparatus of claim 1 wherein said plurality of laboratory instruments configured to run tests relating to at least one patient includes at least one of said plurality of host computers in communication with a first of said plurality of laboratory instruments as an integral part of said first laboratory instrument.

4. The laboratory instrument information management and control apparatus of claim 1 wherein said predetermined communication protocol governs data exchange, data management and integration of data in accordance with IEEE 1073 standard for Medical Device Communications.

5. The laboratory instrument information management and control apparatus of claim 1 wherein said each of said plurality of host computers is in communication with at least one of said plurality of laboratory instruments via at least one of a wireless connection, a serial connection, a parallel connection and an Ethernet connection.

6. The laboratory instrument information management and control apparatus of claim 1 wherein said LIS is in communication with the interface point server via at least one of an Ethernet connection and an Internet connection.

7. The laboratory instrument information management and control apparatus of claim 1 wherein said plurality of laboratory instruments comprises at least two automated slide staining systems in communication with one of the plurality of host computers, and said second level interface communicates with the one host computer to control data sharing among said at least two automated slide staining systems.

8. The laboratory instrument information management and control apparatus of claim 7 wherein said data sharing among said at least two automated slide staining systems includes sharing data comprising data elements associated with staining protocols;

user passwords and privileges;

reagent dispensers;

reagent vials;

cases;

keycodes;

templates;

panels; and

3^rd party reagents.

9. The laboratory instrument information management and control apparatus of claim 1 wherein said laboratory information system manages the workflow for anatomical pathology in a laboratory, including at least one of pathology order placement;

slide processing optimization on multiple instruments;

slide identification through the process;

bar code use;

reagent use and supply;

reagent sharing between laboratory instruments; and

operator in-service qualification.

10. The laboratory instrument information management and control apparatus of claim 1 wherein said laboratory information system is a hospital laboratory information system.

11. The laboratory instrument information management and control apparatus of claim 1, further comprising:

a computer readable medium of the IPS comprising code stored thereon for broadcasting a message by said second level interface to said plurality of host computers, said message including information regarding said data elements in said data element storage of the IPS;

a computer readable medium, included in each of the plurality of host computers having data element sharing enabled, comprising code stored thereon for performing processing including;

receiving the message broadcast by the second level interface;

determining, using at least a portion of said information included in said message, whether differences exist between host data of said each host computer and said data elements being shared as included in said data element storage; and

if differences exist and include a first difference indicating that either a third data element of the host data is not included in the data element storage of the IPS, or a copy of the third data element of the host data is newer than a copy of the third data element of the data element storage of the IPS, updating the data element storage of the IPS to include the third data element of the host data.

12. A computer implemented method for communication between a laboratory information system and a plurality of host computers comprising the steps of:

configuring an interface point network including an interface point server (IPS) in communication with a laboratory information system and a plurality of host computers managing data and control for a plurality of anatomical pathology laboratory instruments, each of said plurality of host computers including host data and being in communication with a portion of said plurality of laboratory instruments, wherein said interface point server includes a first interface software and a second interface software, wherein each of said plurality of host computers is independently configured with data sharing enabled or disabled, said second interface software facilitating replication of data elements shared between said plurality of host computers, said data elements that are shared being stored in a data element storage of said IPS;

determining, by a first of the plurality of host computers that said first host computer requires use of a reagent whereby, in order for the first host computer to use the reagent, the first host computer requires ownership of a first data element associated with the reagent;

sending, by said first host computer to each other host computer of the plurality of host computers, a request requesting ownership of the first data element;

receiving, at said each other host computer, the request from the first host computer;

determining, in accordance with information of a data element database of said each other host computer, whether said each other host computer currently owns the first data element and, if so, whether said first data element is locked; and

responsive to determining that said each other host computer is current owner of the first data element and the first data element is not locked, updating the data element database of said each other host computer to indicate the first host computer as current owner of the first data element rather than said each other host computer, and sending, by said each other host computer to the first host computer, a message indicating that the first host computer is current owner of the first data element thereby indicating the first host computer as current owner of the reagent associated the first data element.

13. The method of claim 12 wherein the method further includes the step of sharing of data among said plurality of host computers.

14. The method of claim 13 wherein said sharing of data among said plurality of host computers includes sharing data comprising data elements associated with staining protocols;

user passwords and privileges;

reagent dispensers;

reagent vials;

cases;

keycodes;

templates;

panels; and

3^rd party reagents.

15. The method of claim 12 wherein said laboratory information system manages the workflow for anatomical pathology in a laboratory, including at least one of pathology order placement;

slide processing optimization on multiple instruments;

slide identification through the process;

bar code use;

reagent use and supply;

reagent sharing between laboratory instruments; and

operator in-service qualification.

16. The method of claim 12 wherein at least one of said plurality of host computers managing data and control for said plurality of anatomical pathology laboratory instruments is an integral part of a first of said anatomical pathology laboratory instruments.

17. The method of claim 12 wherein said interface point server (IPS) in communication with said laboratory information system communicates via a predetermined communication protocol that governs data exchange, data management and integration of data in accordance with IEEE 1073 standard for Medical Device Communications.

18. The method of claim 12 further comprising:

operating said interface point server to broadcast, by said second interface software, a message across said interface point network, wherein said message includes information regarding data elements in the data element storage of said IPS; and

performing processing by each of said plurality of host computers having data element sharing enabled, said processing including;

receiving the message broadcast by the second interface software;

responsive to said each host computer receiving said message, determining if differences exist between said host data of said each host computer and said data elements in said data element storage of said IPS using information included in said message received; and

if differences exist and include a first difference indicating that either a second data element of the host data of said each host computer is not included in the data element storage of the IPS, or a copy of the second data element of the host data of said each host computer is newer than a copy of the second data element of the data element storage of the IPS, updating said data element storage of said IPS to include the second data element of said host data of said each host computer.

19. The method of claim 18, wherein said message includes a protocol version number associated with a version of data stored at said IPS, said protocol version number being included in said information used in said determining if differences exist between said host data and said data elements in the data element storage of said IPS.

24. The method of claim 19, wherein said message is received by said first host and said host data is data stored at the first host, and the method further comprising:

comparing said protocol version number with another protocol version number associated with said host data; and

if said comparing determines that said protocol version number is not different than said another protocol version number, determining that said host data and said data elements of said data element storage said IPS are the same.

25. The method of claim 24, wherein, if said comparing determines that said protocol version number is different than said another protocol version number, determining that said host data and said data elements of said data element storage of said IPS are not the same and performing first processing including:

requesting, by said first host, a first list of data elements stored in said data element storage at said IPS;

receiving, by said first host from said IPS, said first list;

building, by said first host, a second list of data elements based on said host data on said first host;

comparing said first list and said second list to determine whether any data elements of said first list are missing from said second list and to determine whether any data elements of said first list are newer than corresponding data elements of said second list;

requesting, by said first host from said IPS, any data elements from said data element storage of said IPS as determined in accordance with said comparing; and

saving, by said first host, any data elements received from said IPS as determined in accordance with said comparing to update said host data of said first host.

26. The method of claim 25, further comprising:

comparing said first list and said second list to determine whether any data elements of said second list are missing from said first list and to determine whether any data elements of said second list are newer than corresponding data elements of first second list; and

sending, by said first host, any data elements to said IPS as determined in accordance with said comparing to update said data elements of said data element storage of said IPS.

27. The method of claim 25, wherein prior to said first host requesting any data elements from said IPS as determined in accordance with said comparing, said first host acquires a data element lock from said IPS.

28. The method of claim 26, wherein prior to said first host sending any data elements to said IPS as determined in accordance with said comparing, said first host acquires a data element lock from said IPS.

20. A computer implemented method for laboratory instrument information management and control, comprising the steps of:

configuring a Laboratory Information System (US) to manage patient and laboratory information in accordance with a protocol for information exchange between applications;

configuring at least two automated slide staining laboratory instruments to run anatomical pathology tests including automated staining of at least one sample relating to at least one patient;

configuring a plurality of host computers each in communication with at least a portion of said at least two slide staining laboratory instruments;

configuring a server in communication with said plurality of host computers and said LIS, said server comprising a first level interface for data communication and control between said LIS and said server, and said server comprising a second level interface for data communication and control between said at least two automated slide staining laboratory instruments and said server, wherein said server is further configured for data sharing among said plurality of host computers and said at least two automated slide staining laboratory instruments, wherein said first level interface and said second level interface are software interfaces, each of said plurality of host computers is independently configured with data sharing enabled or disabled, said second level interface facilitating replication of data elements shared between said plurality of host computers, said data elements that are shared being stored in a data element storage of said server;

determining, by a first of the plurality of host computers that said first host computer requires use of a reagent whereby, in order for the first host computer to use the reagent, the first host computer requires ownership of a first data element associated with the reagent;

sending, by said first host computer to each other host computer of the plurality of host computers, a request requesting ownership of the first data element;

receiving, at said each other host computer, the request from the first host computer;

determining, in accordance with information of a data element database of said each other host computer, whether said each other host computer currently owns the first data element and, if so, whether said first data element is locked; and

responsive to determining that said each other host computer is current owner of the first data element and the first data element is not locked, updating the data element database of said each other host computer to indicate the first host computer as current owner of the first data element rather than said each other host computer, and sending, by said each other host computer to the first host computer, a message indicating that the first host computer is current owner of the first data element thereby indicating the first host computer as current owner of the reagent associated the first data element.

21. The method for laboratory instrument information management and control of claim 20 wherein said data sharing among said at least two automated slide staining laboratory-instruments-includes sharing data-comprising data elements associated with staining protocols;

user passwords and privileges;

reagent dispensers;

reagent vials;

cases;

keycodes;

templates;

panels; and

3^rd party reagents.

22. The method for laboratory instrument information management and control of claim 20 wherein said laboratory information system manages the workflow for anatomical pathology in a laboratory, including at least one of pathology order placement;

slide processing optimization on multiple instruments;

slide identification through the process;

bar code use;

reagent use and supply;

reagent sharing between laboratory instruments; and

operator in-service qualification.

23. The method of claim 20 wherein said server in communication with said laboratory information system communicates via a predetermined communication protocol that governs data exchange, data management and integration of data in accordance with IEEE 1073 standard for Medical Device Communications.

29. The method of claim 20, further comprising:

receiving, by said server, a message in accordance with a protocol at an application level;

extracting, by said server, data from said message in accordance with rules including an interpreted list of instructions to map extracted data into data elements; and

periodically broadcasting a message to at least one host in accordance with a transport level protocol of a multi-level software architecture in connection with data synchronization between said at least one host and said server.

30. The method of claim 20, further comprising:

broadcasting a message by said second level interface to said plurality of host computers, said message including information regarding said data elements which are shared and are stored in the data element storage of the server; and

performing processing by each of said plurality of host computers having data element sharing enabled, said processing including;

receiving the message broadcast by the second level interface;

determining, using at least a portion of said information included in said message, whether differences exist between host data of said each host, computer and said data elements being shared as included in said data element storage of the server; and

if differences exist and include a first difference indicating that either a second data element of the host data of said each host computer is not included in the data element storage of the IPS, or a copy of the second data element of the host data of said each host computer is newer than a copy of the second data element of the data element storage of the IPS, updating said data element storage of said IPS to include the second data element of said host data of said each host computer.

31. A computer implemented method for maintaining ownership of a reagent represented by a data element comprising:

associating said reagent with said data element;

determining that a first host requires use of said reagent whereby, in order for the first host to use the reagent, the first host requires ownership of the data element associated with said reagent;

sending, by said first host to each of a plurality of hosts, a request requesting ownership of the data element; and

receiving, by each of said plurality of hosts, said request, and wherein, in response to receiving said request, said each host performs first processing, said first processing including;

determining, in accordance with information of a data element database of said each host, whether said each host currently owns said data element and if so, determining whether said data element is locked; and

responsive to determining that said each host is current owner of said data element and said data element is not locked, updating said data element database of said each host to indicate said first host as the current owner of said data element rather than said each host, and sending, by said each host to said first host, a message to said first host indicating that said first host is the current owner of said data element, the current owner of the data element being indicated as current owner of the reagent associated therewith.

32. The method of claim 31, wherein said updating said data element database includes writing information about the first host, said information written about the first host including a host identifier of the first host and a timestamp of said updating.

33. The method of claim 31, wherein said first processing further comprises:

receiving, by said first host, said message;

sending, by said first host to said each host, an acknowledgement message; and

updating a second data element database of said first host in accordance with said message to record said first host as said current owner of the data element.

34. A non-transitory computer readable medium comprising code stored thereon for communication between a laboratory information system and at least one host computer, the computer readable medium comprising code stored thereon for:

configuring an interface point network including an interface point;

server (IPS) in communication with a laboratory information system and a plurality of host computers managing data and control for a plurality of anatomical pathology laboratory instruments, each of said plurality of host computers including host data and being in communication with a portion of said plurality of laboratory instruments, wherein said interface point server includes a first interface software and a second interface software, wherein each of said plurality of host computers is independently configured with data sharing enabled or disabled, said second interface software facilitating replication of data elements shared between said plurality of host computers, said data elements that are shared being stored in a data element storage of said IPS;

determining, by a first of the plurality of host computers that said first host computer requires use of a reagent whereby, in order for the first host computer to use the reagent, the first host computer requires Ownership of a first data element associated with the reagent;

sending, by said first host computer to each other host computer of the plurality of host computers, a request requesting ownership of the first data element;

receiving, at said each other host computer, the request from the first host computer;

determining, in accordance with information of a data element database of said each other host computer, whether said each other host computer currently owns the first data element and, if so whether said first data element is locked; and

responsive to determining that said each other host computer is current owner of the first data element and the first data element is not locked, updating the data element database of said each other host computer to indicate the first host computer as current owner of the first data element rather than said each other host compute and sending, by said each other host computer to the first host computer, a message indicating that the first host computer is current owner of the first data element thereby indicating the first host computer as current owner of the reagent associated the first data element.

35. A non-transitory computer readable medium comprising code stored thereon for laboratory instrument information management and control, the computer readable medium comprising code stored thereon for:

configuring a Laboratory Information System (LIS) to manage patient and laboratory information in accordance with a protocol for information exchange between applications;

configuring at least two automated slide staining laboratory instruments to run anatomical pathology tests including automated staining of at least one sample relating to at least one patient;

configuring a plurality of host computers each in communication with at least a portion of said at least two slide staining laboratory instruments;

configuring a server in communication with said plurality of host computers and said LIS, said server comprising a first level interface for dam communication and control between said LIS and said server, and said server comprising a second level interface for data communication and control between said at least two automated slide staining laboratory instruments and said server, wherein said server is further configured for data sharing among said plurality of host computers and said at least two automated slide staining laboratory instruments, wherein said first level interface and said second level interface are software interfaces, each of said plurality of host computers is independently configured with data sharing enabled or disabled, said second level interface facilitating replication of data elements shared between said plurality of host computers, said data elements that are shared being stored in a data element storage of said server;

determining, by a first of the plurality of host computers that said first host computer;

requires use of a reagent whereby, in order for the first host computer to use the reagent, the first host computer requires ownership of a first data element associated with the reagent;

sending by said first host computer to each other host computer of the plurality of host computers, a request requesting ownership of the first data element;

receiving, at said each other host computer, the request from the first host computer;

determining in accordance with information of a data element database of said each other host computer, whether said each other host computer currently owns the first data element and, if so, whether said first data element is locked; and

responsive to determining that said each other host computer is current owner of the first data element and the first data element is not locked, updating the data element database of said each other host computer to indicate the first host computer as current owner of the first data element rather than said each other host computer, and sending, by said each other host computer to the first host computer a message indicating that the first host computer is current owner of the first data element thereby indicating the first host computer as current owner of the reagent associated the first data element.