Non-invasive method and device for measuring cardiac output

• US 8,721,559 B2
• Filed: 01/05/2009
• Issued: 05/13/2014
• Est. Priority Date: 01/04/2008
• Status: Expired due to Fees

• Current Assignee: SARCOS LC (Sarcos Technology & Robotics Corp.)
• Original Assignee: Raytheon Company (Rtx Corporation)
• Inventors: Peterson, Stephen C., Petelenz, Tomasz J., Jacobsen, Stephen C.
• Primary Examiner(s): Schaetzle, Kennedy
• Assistant Examiner(s): LEE, ERICA SHENGKAI
• Application Number:
  US12/348,842
• Publication Number:
  US 20100022900A1
• Time in Patent Office: 1,954 Days
• Field of Search: 600/526, 607/32, 607/60, 607/65
• US Class Current: 600/526
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves

Abstract

A system comprising a housing containing a signal generator coupled to an antenna and a dielectric material disposed about the antenna. The device is adapted to generate and direct a plurality of signals towards the heart of the person and measure a magnitude of a signal returned from the heart. The device further comprises a processor to compare differences between a magnitude of a signal propagated and the magnitude of the signal returned off the heart and determine a signal frequency having a maximum return loss value based on those differences. The processor also estimates a change in the amplitude of motion of a portion of a wall of the heart based on the differences between the magnitude of the signal propagated by the device and the magnitude of the signal returned off of the portion of the heart.

Claims

1. A system for measuring cardiac parameters of the heart of a person, comprising:

a device comprising a housing containing a signal generator coupled to an antenna and a dielectric material disposed about the antenna, wherein said device is adapted to repeatedly generate a sweep of radio frequency signals at a plurality of frequencies and direct said signals towards the heart of the person and measure magnitudes of signals returned off the heart of the person; and

a processor contained within said housing, said processor being adapted to compare magnitudes of the radio frequency signals propagated into the heart of the person and magnitudes of the signals returned from the heart to determine return loss values for each of the radio frequency signals,

said processor being adapted to determine a maximum return loss value for each sweep of radio frequency signals and estimate a change in the amplitude of motion of a portion of a wall of the heart based on changes in the maximum return loss values.

2. The system of claim 1, wherein said processor is further adapted to calculate the cardiac output of the person;

and further comprising a display disposed about the device adapted to display the measured signals and that can be calibrated to display the estimated stroke volume of the person.

3. The system of claim 2, wherein said processor is further adapted to calculate the cardiac parameters of the person based on an estimated stroke volume of the person.

4. The system of claim 1, wherein said device is adapted to generate a signal at a frequency and magnitude having a determined maximum return loss value into the portion of the heart and receive a portion of the signal propagated into the portion of the heart.

5. The system of claim 1, wherein the dielectric material is selected from the group consisting of ceramics, glass, liquids, gels and polymeric materials.

6. The system of claim 3, wherein said processor is further adapted to estimate the stroke volume of the heart based on a change of the amplitude of motion of the portion of the wall of the heart.

7. The system of claim 6, wherein said processor is adapted to estimate the timing of a QRS complex of the heart based on the change of the amplitude of motion of the portion of the wall of the heart.

8. The system of claim 6, wherein said processor is further adapted to estimate the timing a QRS complex of the heart based on a change of a frequency of a signal having the maximum return loss value.

9. The system of claim 1, wherein the dielectric material has a predetermined thickness and a predetermined dielectric constant such that a substantial portion of a near field component of the radio frequency signals propagated towards the heart of the person is contained within said dielectric material.

10. The system of claim 1, wherein the dielectric material has a predetermined thickness and a predetermined dielectric constant such that substantially an entire near field component of the radio frequency signals propagated towards the heart of the person is contained within said dielectric material.

11. A method for measuring cardiac parameters of a person, comprising:

(a) placing a device about the center of the chest of the person at the mid-sternum position, said device comprising a signal generator coupled to an antenna, said antenna having a dielectric material disposed about the exterior of the antenna;

(b) propagating a first signal having a predetermined frequency towards the heart of the person;

(c) receiving and measuring a portion of the first signal returned from the heart of the person with the device;

(d) comparing the magnitude of the first signal propagated into the heart of the person to the magnitude of the portion of the first signal returned from the heart of the person and calculating a return loss of the signal;

(e) repeating steps (b) through (d) for a plurality of signals while incrementally varying the frequency of the additional signals over a predetermined frequency range; and

(f) determining a maximum return loss value of the signals propagated into the heart of the person over the predetermined frequency range; and

(g) repeating steps (b) through (f) and estimating a change in the amplitude of motion of a portion of a wall of the heart based on changes in maximum return loss values.

12. The method of claim 11, wherein the first signal and the plurality of signals comprise a radio frequency signal.

13. The method of claim 11, wherein the dielectric material is selected from the group consisting of ceramics, glass, liquids, gels and other polymeric materials.

14. The method of claim 11, further comprising estimating impedance of the tissues inside the thorax of the person.

15. The method of claim 14, further comprising estimating a change in the impedance of the tissues inside the thorax of the person.

16. The method of claim 15, further comprising estimating a stroke volume of the heart based on the change in the impedance of the tissues inside the thorax of person.

17. The method of claim 15, further comprising determining the timing of a QRS complex of the heart based on a change in the magnitude of the maximum return loss values.

18. The method of claim 15, further comprising determining the timing of a QRS complex of the heart based on a change in frequency of the maximum return loss values.

19. The method of claim 11, wherein the portion of the heart comprises a right ventricle of the heart.

20. A method for measuring cardiac output of a person, comprising:

(a) placing a hand-held device about the person, said device comprising a radio frequency signal generator coupled to an antenna;

(b) propagating a sweep of signals having a constant magnitude into a portion of the heart of the person wherein each signal of the sweep of signals has a different frequency;

(c) receiving and measuring a portion of the sweep of signals returned from the heart of the person with the device; and

(d) determining, out of the sweep of signals returned from the heart of the person, the signal of maximum return loss;

(e) repeatedly generating sweeps of signals having a constant magnitude at a plurality of frequencies and directing said signals towards the heart of the person and measuring magnitudes of the signals returned off the heart of the person to determine a return loss of each signal;

(f) determining a maximum return loss value for each sweep of radio frequency signals; and

(g) estimating a change in the amplitude of motion of a portion of a wall of the heart based on changes in maximum return loss values.

21. A method for estimating a volume of fluid within the thorax of a person, comprising:

(a) placing a device about the chest of the person, said device comprising a signal generator coupled to an antenna, said antenna having a dielectric material disposed about the exterior of the antenna;

(b) propagating a first signal having a predetermined frequency towards the thorax of the person;

(c) receiving and measuring a portion of the first signal returned from the thorax of the person with the device;

(d) comparing the magnitude of the first signal propagated into the thorax of the person to the magnitude of the portion of the first signal returned from the thorax of the person and calculating a return loss of the signal;

(e) repeating steps (b) through (d) for a plurality of signals while incrementally varying the frequency of the additional signals over a predetermined frequency range; and

(f) determining a maximum return loss value of the signals propagated into the thorax of the person over the predetermined frequency range; and

(g) repeating steps (b) through (f) and estimating a change in the amplitude of motion of a portion of a wall of an organ within the thorax based on changes in maximum return loss values.

22. A system for estimating a volume of fluid within the thorax of a person, comprising:

a device comprising a housing containing a signal generator coupled to an antenna and a dielectric material disposed about the antenna, wherein said device is adapted to repeatedly generate a sweep of radio frequency signals at a plurality of frequencies and direct said signals towards the thorax of the person and measure magnitudes of signals returned off the thorax of the person;

a processor contained within said housing, said processor being adapted to compare magnitudes of the radio frequency signals propagated into the thorax of the person and magnitudes of the signals returned from the thorax to determine return loss values for each of the radio frequency signals; and

said processor being adapted to determine a maximum return loss value for each sweep of radio frequency signals and estimate a change in the amplitude of motion of a portion of a wall of an organ within the thorax based on changes in the maximum return loss values.

23. A method for estimating a volume of fluid within the thorax of a person, comprising:

(a) placing a hand-held device about a person, said device comprising a radio frequency signal generator coupled to an antenna;

(b) propagating a sweep of signals having a constant magnitude into a portion of the thorax of the person wherein each signal of the sweep of signals has a different frequency;

(c) receiving and measuring a portion of the sweep of signals returned from the thorax of the person with the device; and

(d) determining, out of the sweep of signals returned from the thorax of the person, the signal of maximum return loss;

(e) repeatedly generating sweeps of signals having a constant magnitude at a plurality of frequencies and directing said signals towards the thorax of the person and measuring magnitudes of the signals returned off the thorax of the person to determine a return loss of each signal;

(f) determining a maximum return loss value for each sweep of radio frequency signals; and

(g) estimating a change in the amplitude of motion of a portion of a wall of an organ within the thorax based on changes in maximum return loss values.