Compositions and methods for surface abrasion with frozen particles

• US 8,721,583 B2
• Filed: 10/31/2008
• Issued: 05/13/2014
• Est. Priority Date: 10/31/2008
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Cook, Daniel B., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): HARWARD, SOREN T
• Application Number:
  US12/290,677
• Publication Number:
  US 20100114545A1
• Time in Patent Office: 2,020 Days
• US Class Current: 604/65
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 51/1027 against receptors, cell-surface antigens or cell-surface determinants
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 5/3015 for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow cell injection devices C12M3/006
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A system, comprising:

at least one computing device;

one or more instructions that when executed on the computing device cause the computing device to receive a first input associated with a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a first subject;

one or more instructions that when executed on the computing device cause the computing device to compare a value associated with the first possible dataset with a second dataset including values representative of predictive regimen parameters related to a second subject with one or more similar or dissimilar physical attributes;

one or more instructions that when executed on the computing device cause the computing device to determine from the comparison at least one frozen particle composition treatment regimen for the first subject, the at least one frozen particle composition treatment regimen including administering to a subject by a remote controlled device a plurality of frozen particle compositions including one or more sub-sets of frozen particle compositions having different therapeutic agents and at least one tracer agent, wherein the sub-sets are delivered according to a pre-determined sequential order;

at least one imaging device configured to measure and provide real-time feedback control for the amount of the at least one frozen particle composition delivered to at least one subject; and

output information.

2. The system of claim 1, wherein the output information is based on the determination.

3. The system of claim 1, wherein the treatment regimen includes at least one of cellular or tissue removal, cellular or tissue ablation, debridement, delivery of at least one therapeutic agent, cleaning one or more wounds, removing material from at least one biological tissue, or removing material from at least one blood vessel.

4. The system of claim 1, wherein the frozen particle composition includes at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, diethyl ether, nitrogen, carbon dioxide, hydrogen oxide, helium, neon, xenon, krypton, chlorine, bromine, oxygen, air, or argon.

5. The system of claim 1, further including one or more instructions that when executed on the at least one computing device cause the at least one computing device to access the first possible dataset in response to the first input.

6. The system of claim 1, further including one or more instructions that when executed on the at least one computing device cause the at least one computing device to generate the first possible dataset in response to the first input.

7. The system of claim 1, further including one or more instructions that when executed on the at least one computing device cause the at least one computing device to determine a graphical illustration of the first possible dataset.

8. The system of claim 1, further including one or more instructions that when executed on the at least one computing device cause the at least one computing device to determine a graphical illustration of the second possible dataset.

9. The system of claim 1, wherein the at least one computing device includes one or more desktop computer, workstation computer, computing system including a cluster of processors, a networked computer, a tablet personal computer, a laptop computer, a mobile device, a mobile telephone, or a personal digital assistant computer.

10. The system of claim 1, wherein the at least one computing device is configured to communicate with a database to access the first possible dataset.

11. The system of claim 1, wherein the at least one computing device is configured to communicate with a frozen particle composition selecting apparatus.

12. The system of claim 1, wherein the at least one computing device is configured to communicate with a frozen particle composition generating apparatus.

13. The system of claim 1, wherein the frozen particle composition includes hydrogen oxide particles in one or more phases including amorphous solid water, low density amorphous ice, high density amorphous ice, very high density amorphous ice, clathrate ice, hyperquenched glassy water, ice Ic, ice Ih, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, or ice XIV.

14. The system of claim 1, wherein the frozen particles have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

15. The system of claim 1, wherein the frozen particle composition further includes at least one of an abrasive, reinforcement agent, therapeutic agent, or explosive agent.

16. The system of claim 1, wherein the frozen particle composition further includes at least one of a polymer, biopolymer, nanoparticle, or detection material.

17. The system of claim 16, wherein the detection material includes at least one electronic identification device.

18. The system of claim 17, wherein the at least one electronic identification device includes at least one radio frequency identification device.

19. The system of claim 17, wherein the detection material includes at least one radioactive element.

20. The system of claim 16, wherein the detection material includes at least one colorimetric substance.

21. The system of claim 20, wherein the at least one colorimetric substance includes one or more of a dye, pigment, or light-emitting substance.

22. The system of claim 21, wherein the light-emitting substance includes at least one of a fluorescent substance, phosphorescent substance, or quantum dot.

23. The system of claim 17, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

24. A system, comprising:

at least one computing device;

one or more instructions that when executed on the computing device cause the computing device to receive a first input associated with a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a first subject;

one or more instructions that when executed on the computing device cause the computing device to compare a value associated with the first possible dataset with a second dataset including values representative of predictive regimen parameters related to a second subject with one or more similar or dissimilar physical attributes;

one or more instructions that when executed on the computing device cause the computing device to determine from the comparison at least one frozen particle composition treatment regimen for the first subject, the at least one frozen particle composition treatment regimen including administering to a subject by a remote controlled device a plurality of frozen particle compositions including one or more sub-sets of frozen particle compositions having different therapeutic agents and at least one tracer agent, wherein the sub-sets are delivered according to a pre-determined pattern with a remote controlled robotic delivery device at a velocity of at least 50 meters per second to the first subject;

at least one imaging device configured to measure and provide real-time feedback control for the amount of the at least one frozen particle composition delivered to at least one subject; and

output information.