Methods and systems for determining an intravenous insulin infusion rate to correct hyperglycemia of a patient, to maintain euglycemia of a patient, and to prevent hypoglycemia of a patient
First Claim
1. A system for determining an intravenous insulin infusion rate to correct hyperglycemia of a patient, the system comprising:
- (a) a measurement receiver configured to receive a glycemic measurement of a patient; and
(b) an insulin infusion rate calculator configured to;
(i) estimate a maintenance rate (MR) of insulin infusion to maintain euglycemia in the patient;
(ii) determine a relationship between a current blood glucose concentration of the patient and a target blood glucose concentration;
(iii) determine an MR-dependent insulin infusion rate (IR) based on the estimated MR and based on the relationship between the current blood glucose concentration and the target blood glucose concentration, wherein determining the MR-dependent IR includes assigning the patient to an iso-MR function that defines a relationship between IR values and blood glucose concentrations based on distance from target, and which during hyperglycemia is based on an ideal rate of descent of blood glucose concentration;
(iv) measure a glycemic response of the patient while using the determined IR;
(v) re-estimate the MR based on the glycemic response of the patient at a previous IR; and
(vi) repeatedly perform steps (ii)-(v), wherein the estimated MR in step (v) during each nth iteration is utilized to determine the IR in step (iii) of each (n+1)th iteration, n being an integer.
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Accused Products
Abstract
Methods and systems for determining an intravenous infusion rate to correct hyperglycemia of a patient, to maintain euglycemia of a patient, and to prevent hypoglycemia are disclosed. In one aspect, a method for determining an intravenous insulin infusion rate to correct hyperglycemia of a patient includes estimating an insulin infusion maintenance rate to maintain euglycemia in a patient. Further, a relationship between a current blood glucose concentration of the patient and a target blood glucose concentration may be determined. An insulin infusion rate may be determined based on the estimated insulin infusion maintenance rate and based on the relationship between the current blood glucose concentration and the target blood glucose concentration. A glycemic response of the patient may be measured while using the determined insulin infusion rate. The insulin infusion maintenance rate is re-estimated based on the glycemic response of the patient at a previous insulin infusion rate.
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Citations
7 Claims
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1. A system for determining an intravenous insulin infusion rate to correct hyperglycemia of a patient, the system comprising:
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(a) a measurement receiver configured to receive a glycemic measurement of a patient; and (b) an insulin infusion rate calculator configured to; (i) estimate a maintenance rate (MR) of insulin infusion to maintain euglycemia in the patient; (ii) determine a relationship between a current blood glucose concentration of the patient and a target blood glucose concentration; (iii) determine an MR-dependent insulin infusion rate (IR) based on the estimated MR and based on the relationship between the current blood glucose concentration and the target blood glucose concentration, wherein determining the MR-dependent IR includes assigning the patient to an iso-MR function that defines a relationship between IR values and blood glucose concentrations based on distance from target, and which during hyperglycemia is based on an ideal rate of descent of blood glucose concentration; (iv) measure a glycemic response of the patient while using the determined IR; (v) re-estimate the MR based on the glycemic response of the patient at a previous IR; and (vi) repeatedly perform steps (ii)-(v), wherein the estimated MR in step (v) during each nth iteration is utilized to determine the IR in step (iii) of each (n+1)th iteration, n being an integer. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A system for determining an intravenous insulin infusion rate to maintain euglycemia of a patient, the system comprising:
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(a) a measurement receiver configured to receive a glycemic measurement of a patient; and (b) an insulin infusion rate calculator configured to; (i) estimate a maintenance rate (MR) of insulin infusion to maintain euglycemia in the patient; (ii) determine a relationship between a current blood glucose concentration of the patient and a target blood glucose concentration; (iii) determine an MR-dependent insulin infusion rate (IR) based on the estimated maintenance rate, wherein determining the MR-dependent IR includes assigning the patient to an iso-MR function that defines a relationship between IR values and blood glucose concentrations based on distance of blood glucose from target and, in case of hyperglycemia, based on an ideal rate of descent of blood glucose concentration; (iii) measure a glycemic response of the patient to an insulin infusion given to the patient using the determined IR; (iv) re-estimate the MR based on the glycemic response of the patient; and (v) repeatedly perform functions (ii)-(iv), wherein the estimated MR in function (iv) during each nth iteration is utilized to calculate the IR in function (ii) of each (n+1)th iteration, n being an integer.
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Specification