Automated system for continuously and automatically calibrating electrochemical sensors
First Claim
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1. A blood chemistry analysis system, comprising:
- (a) one or more sensors in a sensor assembly for performing a first measurement and a second measurement of an analyte in at least one internal reference solution, said internal reference solution comprising a known concentration of said analyte;
(b) a storage element operably coupled to the one or more sensors for storing;
(i) data representing the first measurement of concentration of the analyte in the reference solution, and(ii) data representing the second measurement of concentration of the analyte in the reference solution;
(c) a microprocessor, operably coupled to the storage element and microprocessor programmed to compare said data representing;
(i) said known concentration of the analyte and said first measurement,(ii) said known concentration and said second measurement,(iii) said first measurement and said second measurement, and to store said compare data representing said first measurement that is similar to data representing said second measurement, and said data representing said first measurement and said data representing said second measurement are dissimilar to said known concentration of said analyte in said reference solution, wherein said concentration data is stored in said storage element; and
(d) a correction action device in communication with said sensors and reactive to signal from said microprocessors for taking a corrective action when said compare data is stored in said storage element.
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Abstract
An electrochemical sensor system that continuously monitors and calibrates the sensors included in the system. The invention also includes a method for determining failure patterns of a sensor and incorporating into an electrochemical sensor system the ability to recognize the failure pattern and initiate remedial action.
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Citations
20 Claims
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1. A blood chemistry analysis system, comprising:
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(a) one or more sensors in a sensor assembly for performing a first measurement and a second measurement of an analyte in at least one internal reference solution, said internal reference solution comprising a known concentration of said analyte; (b) a storage element operably coupled to the one or more sensors for storing; (i) data representing the first measurement of concentration of the analyte in the reference solution, and (ii) data representing the second measurement of concentration of the analyte in the reference solution; (c) a microprocessor, operably coupled to the storage element and microprocessor programmed to compare said data representing; (i) said known concentration of the analyte and said first measurement, (ii) said known concentration and said second measurement, (iii) said first measurement and said second measurement, and to store said compare data representing said first measurement that is similar to data representing said second measurement, and said data representing said first measurement and said data representing said second measurement are dissimilar to said known concentration of said analyte in said reference solution, wherein said concentration data is stored in said storage element; and (d) a correction action device in communication with said sensors and reactive to signal from said microprocessors for taking a corrective action when said compare data is stored in said storage element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A sensor system comprising:
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(a) a reference solution comprising a known concentration of at least one analyte; (b) a sensor responsive to a concentration of the at least one analyte in the reference solution; (c) a memory operably coupled to the sensor for storing; (i) data representing the known concentration of the analyte in the reference solution, (ii) data representing a first measurement of concentration of the analyte in the reference solution, and (iii) data representing a second measurement of concentration of the analyte in the reference solution; (d) a comparator operably coupled to the memory and configured for comparing; (i) the data representing the known concentration and the data representing the first measurement; (ii) the data representing the known concentration and the data representing second measurement; and (iii) the data representing the first measurement and the data representing the second measurement; and (e) a corrective action device programmed to initiate a corrective action if the data representing the first measurement and the data representing the second measurement are similar to each other but both dissimilar to the data representing known concentration of said analyte in said reference solution. - View Dependent Claims (19, 20)
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Specification