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Assay device

  • US 8,721,990 B2
  • Filed: 04/09/2008
  • Issued: 05/13/2014
  • Est. Priority Date: 04/10/2007
  • Status: Active Grant
First Claim
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1. An assay device for the determination of hCG in a liquid sample over an extended concentration rang, comprising a first assay and a second assay,wherein the first assay comprises a first flow-path having a sole first assay detection zone and a mobilisable, labeled, hCG-binding reagent provided upstream from the first assay detection zone;

  • and the second assay comprises a second flow-path having a sole second assay detection zone, a mobilisable, labeled, hCG-binding reagent provided upstream from the second assay detection zone, and a mobilisable scavenger binding reagent for hCG provided upstream from the second assay detection zone;

    wherein the first and second assay detection zones each independently comprise an immobilised reagent that is capable of immobilising the respective labeled, hCG-binding reagent in the presence of hCG;

    wherein said first and second assays are provided on separate substrates, or on a common substrate but with the first and second flow-paths fluidically isolated from one another;

    wherein the immobilisation of the labeled, hCG-binding reagents at the detection zones provides an indication of hCG in said liquid sample; and

    wherein the first assay provides an indication of hCG in a first concentration range and the second assay provides an indication of hCG in a second, higher concentration range.

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