Compositions and methods for surface abrasion with frozen particles

• US 8,722,068 B2
• Filed: 10/08/2012
• Issued: 05/13/2014
• Est. Priority Date: 10/31/2008
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Cook, Daniel B., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): Sullivan, Daniel
• Assistant Examiner(s): Purdy, Kyle
• Application Number:
  US13/646,880
• Publication Number:
  US 20130071319A1
• Time in Patent Office: 582 Days
• Field of Search: None
• US Class Current: 424/400
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 49/1818 particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
• CPC Class Codes: A61K 51/12 characterised by a special physical form, e.g. emulsion, microcapsules, liposomes , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules liposomes A61K51/1234
• CPC Class Codes: A61K 51/1244 microparticles or nanoparticles, e.g. polymeric nanoparticles
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61K 9/1611 Inorganic compounds
• CPC Class Codes: A61K 9/1641 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1664 Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617
• CPC Class Codes: A61K 9/1688 resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/19 : lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A method for abrasion of at least one biological tissue surface of a subject, comprising:

delivering in a single treatment to at least one biological tissue, at least two pluralities of frozen particle compositions in a predetermined sequential order, the first plurality of frozen particle compositions;

including one or more frozen particles approximately one micrometer or less;

and

wherein the first plurality includes two or more subsets having different therapeutic agents including at least one of ibuprofen, morphine, codeine, aspirin, acetaminophen, lidocaine/lignocaine, ropivacaine, mepivacaine, benzocaine, chloroprocaine, cocaine, cyclomethycaine, dimethocaine/larocaine, propoxycaine, procaine/novocaine, proparacaine, tetracaine/amethocaine, articaine, bupivacaine, carticaine, cincho caine/dibucaine, etidocaine, levobupivacaine, piperocaine, prilocaine, trimecaine, saxitoxin, or tetrodotoxin; and

subsequently in the same treatment, delivering a second plurality of frozen particle compositions;

including one or more frozen particles approximately one micrometer or less;

and wherein the second plurality includes at least two subsets having different agents including one or more of, keratin, collagen, elastin, cytokine, coagulant, anti-coagulant, anti-inflammatory agent, anti-tumor agent, antimicrobial agent, epinephrine, adrenaline, or a neurotoxin.

2. The method of claim 1, wherein the one or more frozen particles are in one or more phases including ice Ic.

3. The method of claim 1, wherein delivering at least one composition to at least one biological tissue includes propelling the composition toward the at least one biological tissue.

4. The method of claim 1, wherein the delivering at least one composition to at least one biological tissue includes propelling, ejecting, or accelerating multiple frozen particles toward the at least one biological tissue.

5. The method of claim 1, further comprising extracting or collecting material from the at least one abraded surface of at least one biological tissue.

6. The method of claim 1, wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, or ex vivo.

7. The method of claim 6, wherein the at least one biological tissue is located in at least one tissue or organ related to transplantation.

8. The method of claim 7, wherein the at least one tissue or organ related to transplantation includes at least one donor or recipient tissue or organ.

9. The method of claim 6, wherein the at least one biological tissue is ingested by at least one subject.

10. The method of claim 1, wherein the at least one biological tissue includes at least one cell mass.

11. The method of claim 1, further including delivering to the at least one biological tissue at least one of a polymer, biopolymer, nanoparticle, or detection material.

12. The method of claim 11, wherein the detection material includes at least one electronic identification device.

13. The method of claim 11, wherein the detection material includes at least one radioactive element.

14. The method of claim 11, wherein the detection material includes at least one colorimetric substance.

15. The method of claim 11, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

16. The method of claim 1, wherein the subject includes at least one invertebrate or vertebrate animal.

17. The method of claim 12, wherein the electronic identification device includes a radio frequency identification device.

18. The method of claim 1, wherein one or more frozen particles in at least one of the first plurality or the second plurality include one or more reinforcement agents of at least one of polyaramid, vinylester matrix, ceramic, fiberglass, broad carbide, aromatic polyamide, nylon, silk, rayon, acetate, modacrylic, olefin, acrylic, polyester, aromatic polyester, vinyon, saran, spandex, vinalon, aromatic nylon, vinylidene chloride, modal, polybenzimidazole, lyocell, orlon, zylon, high-performance polyethylene, polypyridobenzimidazole, vectran, acrylonitrile rubber, glass, or steel.

19. The method of claim 1, wherein the at least one composition is delivered to the biological tissue by way of a handheld device.

20. The method of claim 19, wherein the handheld device includes at least one of a wand, pen, hose, sprayer, or gun.

21. The method of claim 1, wherein the at least one composition is delivered to the biological tissue by way of a device included in a wall, corral, or gate.

22. The method of claim 1, wherein the at least one composition is delivered to the biological tissue by way of a device including a cavity into which a subject may be placed for administration.