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Method for selecting a chemical entity from a tagged library

  • US 8,722,583 B2
  • Filed: 04/13/2006
  • Issued: 05/13/2014
  • Est. Priority Date: 10/30/2002
  • Status: Active Grant
First Claim
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1. In a method of determining the identity of a chemical entity in a combinatorial library comprising a plurality of structurally distinct chemical entities,wherein the chemical entities are non-polymeric compounds,wherein each chemical entity is tagged with an entity tag identifying the structure of the chemical entity,wherein each chemical entity comprises a plurality of fragments,wherein the entity tag consists essentially of a plurality of fragment tags, each fragment tag identifying one of the fragments constituting a fragment of the chemical entity tagged by said entity tag,wherein the identity of at least one chemical entity is determined from the entity tag with which it is tagged,the improvement comprisingligating at least one pair of fragment tags by enzyme-catalysed ligation.

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