Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders
First Claim
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1. A method for treating pain or the perception of pain in a mammalian subject in need thereof comprising administering an effective amount of a composition comprising a Na+K+2Cl−
- co-transporter antagonist to the subject.
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Abstract
The present invention relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders by administering agents that are effective in reducing the effective amount, inactivating, and/or inhibiting the activity of a Na+—K+-2Cl− (NKCC) cotransporter. In certain embodiments, the Na+—K+-2Cl− co-transporter is NKCC1.
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Citations
13 Claims
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1. A method for treating pain or the perception of pain in a mammalian subject in need thereof comprising administering an effective amount of a composition comprising a Na+K+2Cl−
- co-transporter antagonist to the subject.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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