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Modulation of stat5 expression

  • US 8,722,873 B2
  • Filed: 02/22/2010
  • Issued: 05/13/2014
  • Est. Priority Date: 11/06/2003
  • Status: Active Grant
First Claim
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1. A compound comprising a modified oligonucleotide consisting of 12 to 30 linked nucleosides and having:

  • i) a nucleobase sequence comprising at least 8 contiguous nucleobases of a nucleobase sequence selected from the group consisting of the nucleobase sequences recited in SEQ ID NOs;

    12, 15-21, 23, 25-30, 33, 34, 38, 40, 41, 45-52, 54-58, 62-74, 78-82, 85, 87, 155-157, 159-161, 163, 164, 166, 169, 170, 173-181, 184-186, 188, 189, 191, 194, 196-200, 202, 203, 205, 209-211, and 213;

    orii) a nucleobase sequence consisting of the nucleobase sequence of SEQ ID NOs 13, 14, 22, 24, 31, 32, 35, 37, 39, 42-44, 53, 59-61, 75, 76, 83, 84, 86, 88, 89, 158, 162, 165, 167, 171, 172, 182, 183, 187, 190, 192, 193, 195, 201, 204, 206, 207, or 212.

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