Compositions and methods for surface abrasion with frozen particles

• US 8,725,420 B2
• Filed: 10/31/2008
• Issued: 05/13/2014
• Est. Priority Date: 10/31/2008
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Cook, Daniel B., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): HARWARD, SOREN T
• Application Number:
  US12/290,687
• Publication Number:
  US 20100114496A1
• Time in Patent Office: 2,020 Days
• US Class Current: 702/19
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 5/3015 for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow cell injection devices C12M3/006
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/30 relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A system, comprising:

circuitry for receiving a first input associated with a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a first subject;

circuitry for comparing a value associated with the first possible dataset with a second dataset including values representative of predictive regimen parameters related to a second subject with one or more similar or dissimilar physical attributes;

circuitry for determining from the comparison at least one solid frozen particle composition treatment regimen for the first subject, the solid frozen particle composition treatment regimen including administration one or more solid frozen particle compositions including at least one tracer agent by a pellet gun;

circuitry for detecting the at least one tracer agent;

circuitry for communicating real-time feedback control of the amount of the one or more solid frozen particle compositions administered to at least one of the first or the second subject based on the detection of the at least one tracer agent; and

circuitry for providing output information including a graphical illustration of the first possible dataset.

2. The system of claim 1, wherein the output information is based on the comparison.

3. The system of claim 1, wherein the circuitry for receiving a first input associated with a first possible dataset includes circuitry for receiving one or more measurements relating to one or more physical attributes including at least one of height;

weight;

body mass index;

age;

presence or absence of at least one disease or condition;

species;

ethnicity;

race;

allergies;

gender;

thickness of epidermis;

thickness of dermis;

thickness of stratum corneum;

keratin deposition;

collagen deposition;

blood vessel condition;

skin condition;

hair or fur condition;

muscle condition;

tissue condition;

organ condition;

nerve condition;

brain condition;

presence or absence of at least one biological, chemical, or therapeutic agent in the subject;

pregnancy status;

lactation status;

genetic profile;

proteomic profile;

partial or whole genetic sequence;

partial or whole proteomic sequence;

lymph condition, medical history, or blood condition.

4. The system of claim 1, wherein the treatment regimen includes cellular, tissue, or other material removal, cellular, tissue, or other material ablation, debridement, delivery of at least one therapeutic agent, cleaning one or more wounds, removing material from at least one biological tissue, or removing material from at least one blood vessel.

5. The system of claim 1, wherein the solid frozen particle composition includes at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, diethyl ether, nitrogen, carbon dioxide, hydrogen oxide, helium, neon, xenon, krypton, chlorine, bromine, oxygen, air, or argon.

6. The system of claim 1, wherein the circuitry for comparing a value associated with a first possible dataset includes circuitry for comparing one or more predictive regimen parameters including clinical outcome;

secondary effects related to the treatment;

disease stage;

longevity;

or vaccination administration.

7. The system of claim 1, the circuitry for comparing a value associated with the first possible dataset with a second dataset includes circuitry for selecting at least one of quality or quantity related to one or more solid frozen particle compositions, method of administering of one or more solid frozen particle compositions, administration location of one or more solid frozen particle compositions, content of one or more solid frozen particle compositions, timing of administration of one or more solid frozen particle compositions, decrease in a physical dimension of one or more solid frozen particle compositions, or time interval between at least two administrations with one or more solid frozen particle compositions.

8. The system of claim 1, wherein the circuitry for determining from the comparison of the administration to at least one subject of at least one solid frozen particle composition treatment regimen includes circuitry for selecting the combination of at least two parameters selected from quality or quantity related to one or more solid frozen particle compositions, method of administration of one or more solid frozen particle compositions, administration location of one or more solid frozen particle compositions, content of one or more solid frozen particle compositions, timing of administration of one or more solid frozen particle compositions, decrease in a physical dimension of one or more solid frozen particle compositions, or time interval between at least two administrations with one or more solid frozen particle compositions.

9. The system of claim 1, wherein the circuitry for comparing a value associated with the first possible dataset with a second dataset including values representative of predictive regimen parameters includes circuitry for selecting at least one of a clinical outcome;

secondary effects related to the treatment;

disease stage;

longevity;

or vaccination administration.

10. The system of claim 9, wherein the clinical outcome includes a positive clinical outcome or a negative clinical outcome.

11. The system of claim 10, wherein the clinical outcome includes one or more adverse effect, failure to attain a clinical endpoint of a clinical trial, failing to attain a beneficial effect, or measurement of at least one biochemical, biological or physiological parameter.

12. The system of claim 1, wherein the at least one solid frozen particle composition treatment regimen includes administration of at least one solid frozen particle composition.

13. The system of claim 12, wherein the at least one solid frozen particle composition includes at least one of nitrogen, argon, helium, air, oxygen, neon, xenon, krypton, chlorine, bromine, carbon dioxide, polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether.

14. The system of claim 12, wherein the at least one solid frozen particle composition includes at least one of a therapeutic agent, reinforcement agent, abrasive, or explosive material.

15. The system of claim 12, wherein the at least one solid frozen particle composition includes at least one of a polymer, biopolymer, nanoparticle, or detection material.

16. The system of claim 15, wherein the detection material includes at least one electronic identification device.

17. The system of claim 16, wherein the at least one electronic identification device includes at least one radio frequency identification device.

18. The system of claim 15, wherein the at least one detection material includes at least one radioactive material.

19. The system of claim 15, wherein the at least one detection material includes at least one colorimetric substance.

20. The system of claim 15, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

21. The system of claim 1, wherein at least the first or second subject includes one or more of a reptile, mammal, amphibian, bird, or fish.

22. The system of claim 21, wherein at least the first or second subject includes one or more of a human, pet, livestock, undomesticated herd animal, wild animal, or product animal.

23. The system of claim 21, wherein at least the first or second subject includes one or more of a sheep, goat, frog, dog, cat, rat, mouse, vermin, monkey, duck, horse, cow, pig, chicken, shellfish, fish, turkey, llama, alpaca, bison, wolf, fox, coyote, deer, rabbit, guinea pig, yak, chinchilla, mink, reindeer, raccoon, deer, elk, camel, donkey, or mule.