Method and apparatus for estimating features of target materials by using kinetic change information

• US 8,725,427 B2
• Filed: 01/21/2009
• Issued: 05/13/2014
• Est. Priority Date: 01/22/2008
• Status: Active Grant

• Current Assignee: Industry Foundation Of Chonnam National University (Chonnam National University)
• Original Assignee: Yong Gwan Won
• Inventors: Won, Yong Gwan
• Primary Examiner(s): Breene, John
• Assistant Examiner(s): Zhang, Haihui
• Application Number:
  US12/863,985
• Publication Number:
  US 20100292932A1
• Time in Patent Office: 1,938 Days
• Field of Search: 702/33, 702/22, 436/95
• US Class Current: 702/22
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 33/5302 Apparatus specially adapted for immunological test procedures
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: G01N 33/86 involving blood coagulating time or factors, or their receptors
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

Disclosed are a method and an apparatus for estimating the features (concentration, weight, volume, etc.) of target materials, by using kinetic change information along time, when measuring the results of a chemical reaction between two materials, target materials and reactant, with an optical or electrochemical method.

Claims

1. A non-transitory computer-readable recording medium storing a computer program for executing a method of estimating feature values of a measurement target material used in an apparatus for estimating feature values of a measurement target material using kinetic change information in a chemical reaction, the method comprising:

acquiring kinetic change information related to feature values of a measurement target material; and

estimating the feature values of the measurement target material using both the kinetic change information and a previously determined correlation function,

wherein the kinetic change information denotes a change in electrochemical current or voltage of the measurement target material with the passage of time,

wherein the feature values denotes a numerical value which represents at least one of the group consisting of a concentration, an amount, a weight, and an amount ratio of the measurement target material, and

wherein the previously determined correlation function denotes a function which indicates a correlation between the kinetic change information and true measured values that are feature values of the measurement target material from a large amount of data previously measured.

2. The method according to claim 1, wherein the correlation function denotes a correlation between true measured values of the measurement target material and the kinetic change information, the true measured values of the measurement target material being obtained from a plurality of samples in an environment in which interference is eliminated.

3. The method according to claim 2, wherein the correlation function minimizes an average error (E_g) defined in the following Equation 1:

4. The method according to claim 1, wherein the measurement target material is glucose in blood.

5. The method according to claim 4, wherein each of the feature values is concentration and the kinetic change information is information in which a measured value of the glucose concentration changes with the passage of time.

6. An apparatus for estimating feature values of a measurement target material using kinetic change information, comprising:

a kinetic information acquisition unit for acquiring kinetic change information related to feature values of a measurement target material; and

a feature estimation unit for estimating the feature values of the measurement target material using both the kinetic change information and a previously determined correlation function.

7. The apparatus according to claim 6, wherein the correlation function denotes a correlation between true measured values of the measurement target material and the kinetic change information.

8. The apparatus according to claim 6, wherein the measurement target material is glucose in blood.

9. The apparatus according to claim 8, wherein each of the feature values is concentration and the kinetic change information is information in which a measured value of the glucose concentration changes with the passage of time.

10. A non-transitory computer-readable recording medium storing a computer program for executing an error correction method used in an error correction apparatus using kinetic change information, comprising:

acquiring kinetic change information related to feature values of a first material;

estimating feature values of a second material using both the kinetic change information and a previously determined first function;

acquiring estimated errors of the feature values of the first material using both the feature values of the second material and a previously determined second function; and

correcting the feature values of the first material measured without considering interference of the second material, by using the estimated errors of the first material,

wherein the kinetic change information denotes a change in electrochemical current or voltage of a measurement target material with the passage of time,

wherein the feature values denotes a numerical value which represents at least one of the group consisting of a concentration, an amount, a weight, and an amount ratio of the measurement target material, and

wherein the previously determined correlation function denotes a function which indicates a correlation between the kinetic change information and true measured values that are feature values of the measurement target material from a large amount of data previously measured.

11. The error correlation method according to claim 10, wherein the first function denotes a correlation between the feature values of the second material and the kinetic change information.

12. The error correlation method according to claim 11, wherein the first function minimizes a value (E_g) defined in the following Equation 3:

13. The error correction method according to claim 10, wherein the second function denotes a correlation between the feature values of the second material and measurement errors of the first material.

14. The error correction method according to claim 13, wherein the second function minimizes a value (E_f) defined in the following Equation 4,

15. The error correction method according to claim 10, wherein the first material is glucose in blood, and the second material is a red blood cell in blood.

16. The error correction method according to claim 15, wherein each of the feature values is concentration and the kinetic change information is information in which a measured value of the glucose concentration changes with the passage of time.

17. An error correction apparatus, comprising:

a kinetic information acquisition unit for acquiring kinetic change information related to feature values of a first material;

a feature estimation unit for estimating feature values of a second material using both the kinetic change information and a previously determined first function;

an estimated error acquisition unit for acquiring estimated errors of the feature values of the first material using both the feature values of the second material and a previously determined second function; and

a feature correction unit for correcting the feature values of the first material measured without considering interference of the second material, by using the estimated errors of the first material.

18. The error correction apparatus according to claim 17, wherein the first function denotes a correlation between the feature values of the second material and the kinetic change information.

19. The error correction apparatus according to claim 17, wherein the second function denotes a correlation between the feature values of the second material and measurement errors of the first material.

20. The error correction apparatus according to claim 17, wherein the first material is glucose in blood, and the second material is a red blood cell in blood.