Volume status monitor: peripheral venous pressure, hypervolemia and coherence analysis
First Claim
1. A method for compensating a cardiovascular waveform having ventilation-induced variation for pulmonary effort using a processor, the method comprising:
- generating a cardiovascular waveform representing physiological characteristics of a subject;
generating a respiratory signal for the subject; and
using a processor to calculate the total power spectral intensity due to respiration, wherein the calculating the total power spectral intensity due to respiration includes;
compensating the cardiovascular waveform for pulmonary effort by multiplying the power spectrum of the cardiovascular waveform by the power spectrum of the respiratory signal; and
detecting a change in amplitude of ventilation-induced variation (VIV) in the compensated cardiovascular waveform by integrating the resulting compensated waveform over a range of respiratory frequencies, wherein the change in amplitude is reflective of a physiological change in the subject.
2 Assignments
0 Petitions
Accused Products
Abstract
Systems and methods are provided for monitoring changes in blood volume using waveforms in the peripheral vasculature. In particular, the systems and methods relate to detecting ventilation-induced variation (VIV) of waveforms in the peripheral vasculature. Advantageously, the systems and methods may relate to analyzing VIV in peripheral venous pressure (PVP). Thus, the VIV of PVP may be measured, wherein decreased VIV is indicative of decreased blood volume In exemplary embodiments, such as involving spontaneous breathing, it may be necessary to account for changes in respiratory signal strength. Thus systems and methods are also provided for assessing coherence between ventilation and VIV for a flow or pressure waveform. Specifically, coherence is evaluated by comparing the waveform to a detected respiratory signal. Finally, systems and method are provided for distinguishing the impact of respiration on the PG signal during hypervolemia as compared to hypovolemia. Such systems and methods may advantageously be utilized to monitor fluid status during fluid replacement.
-
Citations
22 Claims
-
1. A method for compensating a cardiovascular waveform having ventilation-induced variation for pulmonary effort using a processor, the method comprising:
-
generating a cardiovascular waveform representing physiological characteristics of a subject; generating a respiratory signal for the subject; and using a processor to calculate the total power spectral intensity due to respiration, wherein the calculating the total power spectral intensity due to respiration includes; compensating the cardiovascular waveform for pulmonary effort by multiplying the power spectrum of the cardiovascular waveform by the power spectrum of the respiratory signal; and detecting a change in amplitude of ventilation-induced variation (VIV) in the compensated cardiovascular waveform by integrating the resulting compensated waveform over a range of respiratory frequencies, wherein the change in amplitude is reflective of a physiological change in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
-
15. A system for compensating a cardiovascular waveform having ventilation-induced variation for pulmonary effort, the system comprising:
-
means for generating a cardiovascular waveform representing physiological characteristics of a subject; means for generating a respiratory signal for the subject; and means for calculating the total power spectral intensity due to respiration, wherein the calculating the total power spectral intensity due to respiration includes; compensating the cardiovascular waveform for pulmonary effort by multiplying the power spectrum of the cardiovascular waveform by the power spectrum of the respiratory signal; and detecting a change in amplitude of ventilation-induced variation (VIV) in the compensated cardiovascular waveform by integrating the resulting compensated waveform over a range of respiratory frequencies, wherein the change in amplitude is reflective of a physiological change in the subject. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
-
Specification