Syringe-carpule assembly

• US 8,728,054 B2
• Filed: 10/28/2009
• Issued: 05/20/2014
• Est. Priority Date: 10/29/2008
• Status: Active Grant

• Current Assignee: Synchrojet LLC
• Original Assignee: Synchrojet LLC
• Inventors: Schulhof, Steven
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): Bosques, Edelmira
• Application Number:
  US12/607,498
• Publication Number:
  US 20100106139A1
• Time in Patent Office: 1,665 Days
• Field of Search: 604/82, 604/85, 604/87, 604 89- 91, 604/191, 604/263, 604/184
• US Class Current: 604/518
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2466 by piercing without internal pressure increase A61M5/2429 takes precedence
• CPC Class Codes: A61M 5/31596 comprising means for injection of two or more media, e.g. by mixing

Abstract

A syringe-carpule assembly comprising first and second carpules, a housing holding the first and second carpules in an end-to-end relationship, an outer hollow plunger rod supported by and slidable relative to the housing, and an inner hollow rod having first and second openings and being slidably arranged inside the outer hollow plunger rod. The inner hollow rod is slidable between first and second positions. The inner hollow rod in the first position has the first opening disposed within the first carpule and the second opening disposed within the second carpule. This allows liquid solvent in the second carpule to flow into the first carpule, which comprises an evacuated chamber containing solid matter that dissolves in the presence of that solvent to form a mixture. The second carpule is then removed and the mixture in the first carpule is injected into the patient.

Claims

1. A syringe-carpule assembly comprising a housing, first and second carpules arranged inside said housing with said first carpule in front of said second carpule, an outer hollow plunger rod that passes through and is slidable in a rearward end of said housing, a first member connected to said outer hollow plunger rod and disposed outside said housing to the rear of said rearward end of said housing, an inner hollow rod comprising first and second openings disposed at different longitudinal positions, said inner hollow rod being slidably arranged inside said outer hollow plunger rod, and a second member connected to said inner hollow rod and disposed outside said housing to the rear of said rearward end of said housing, wherein said outer hollow plunger rod is slidable between a first extended position whereat said first member is disposed a first distance from said rearward end of said housing and a first retracted position whereat said first member is disposed a second distance from said rearward end of said housing, said second distance being greater than said first distance, and said inner hollow rod is slidable between a second extended position whereat said second member is disposed a third distance from said rearward end of said housing and a second retracted position whereat said second member is disposed a fourth distance from said rearward end of said housing, said fourth distance being greater than said third distance, and further wherein respective portions of said inner hollow rod are disposed inside said first and second carpules when said inner hollow rod is in said first extended position and outside said first and second carpules when said inner hollow rod is in said first retracted position.

2. The syringe-carpule assembly as recited in claim 1, wherein said first carpule has an evacuated chamber containing solid matter, and said second carpule has a chamber containing liquid solvent.

3. The syringe-carpule assembly as recited in claim 2, wherein said first carpule comprises a glass vial having open front and rear ends, a rubber membrane that closes said open front end of said first vial, and a rubber stopper that closes said open rear end of said first vial, said solid matter being contained inside said first vial between said rubber membrane and said rubber stopper.

4. The syringe-carpule assembly as recited in claim 3, wherein said rubber stopper comprises a flange that is sandwiched between said second carpule and said glass vial of said first carpule.

5. The syringe-carpule assembly as recited in claim 1, further comprising a flexible substrate wrapped around respective portions of said first and second carpules, said flexible substrate having a line of weakened tear resistance.

6. The syringe-carpule assembly as recited in claim 1, wherein said first member comprises an aspirating ring connected to a rearward end of said outer hollow plunger rod.

7. The syringe-carpule assembly as recited in claim 1, further comprising a head connected to a forward end of said outer hollow plunger rod, wherein said head is disposed within said first carpule when said outer hollow plunger rod is in said first extended third position, and said head is not disposed within said first carpule when said outer hollow plunger rod is in said first retracted position.

8. The syringe-carpule assembly as recited in claim 1, wherein said outer hollow plunger rod comprises a cylindrical wall with a longitudinal slot, and said second member comprises a handle connected to said inner hollow rod through said longitudinal slot, said handle being manually operable by an operator to slide said inner hollow rod forward relative to said outer hollow plunger rod.

9. A method of administering a medicine to a patient using a syringe, comprising the following steps:

(a) placing a first carpule containing solid matter in a chamber and a second carpule containing liquid solvent in a chamber inside a housing of a syringe in an end-to-end relationship with said first carpule in front of said second carpule, said chamber of said first carpule having an internal pressure less than atmospheric pressure;

(b) placing a hollow rod of said syringe so that a first opening thereof is located inside said chamber of said first carpule and a second opening thereof is located inside said chamber of said second carpule, thereby causing liquid solvent to flow through said hollow rod and into said chamber of said first carpule, where said liquid solvent dissolves said solid matter to form a mixture;

(c) removing said hollow rod from said chambers of said first and second carpules;

(d) attaching a needle to said syringe housing;

(e) removing said second carpule from said syringe housing; and

(f) forcing at least a portion of said mixture to flow from said chamber of said first carpule into and through said needle.

10. The method as recited in claim 9, wherein step (f) comprises the following steps:

placing a head of a hollow plunger rod in contact with a rubber stopper disposed at a rear end of said first carpule; and

using said hollow plunger rod to push said rubber stopper toward said needle at least until a portion of the mixture inside said first carpule has passed through and exited said needle.

11. The method as recited in claim 9, wherein step (b) comprises the following steps:

piercing a rubber stopper disposed at a rear end of said second carpule, piercing a rubber membrane disposed at a front end of said second carpule, and piercing a rubber stopper disposed at a rear end of said first carpule.

12. The method as recited in claim 9, wherein said solid matter comprises botulinum toxin and said liquid solvent comprises saline.

13. The method as recited in claim 9, further comprising the following step performed prior to step (a):

wrapping a flexible substrate around respective portions of said first and second carpules.

14. The method as recited in claim 13, wherein said flexible substrate has a line of weakened tear resistance, and step (e) comprises the step of tearing said flexible substrate along said line of weakened tear resistance.