Chemotherapeutic composition using nanocrystalline calcium phosphate paste
First Claim
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1. An anticancer composition comprising:
- (i) a calcium phosphate comprising an amorphous calcium phosphate (ACP) or a poorly crystalline apatitic (PCA) calcium phosphate;
(ii) an anticancer agent; and
(iii) a physiologically acceptable fluid,wherein said composition is formulated as a formable or injectable paste that hardens in an endothermic reaction.
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Abstract
A method and composition are provided for treating cancer in a mammal. The method includes administering to a tumor site of the mammal an anticancer composition comprising a mixture of an anticancer agent and a nanocrystalline or poorly crystalline calcium phosphate paste, said paste comprised of one or more calcium phosphates and a physiologically acceptable fluid, the paste having an injectable or formable consistency at the time of administration and hardenable at the tumor.
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12 Claims
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1. An anticancer composition comprising:
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(i) a calcium phosphate comprising an amorphous calcium phosphate (ACP) or a poorly crystalline apatitic (PCA) calcium phosphate; (ii) an anticancer agent; and (iii) a physiologically acceptable fluid, wherein said composition is formulated as a formable or injectable paste that hardens in an endothermic reaction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification