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Compositions and methods for promoting the generation of PDX1+ pancreatic cells

  • US 8,728,812 B2
  • Filed: 04/22/2009
  • Issued: 05/20/2014
  • Est. Priority Date: 04/22/2008
  • Status: Active Grant
First Claim
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1. A method of producing pancreatic Pdx1 expressing cells comprising:

  • a) contacting a population of human embryonic stem cells with Activin A to differentiate them into definitive endoderm cells, andb) exposing the definitive endoderm cells of step a) to an effective amount of at least one compound listed in table 1 to increase the number of Pdx1 expressing cells in the differentiated cell population.

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