Compositions and methods for therapeutic delivery with frozen particles

• US 8,731,840 B2
• Filed: 10/31/2008
• Issued: 05/20/2014
• Est. Priority Date: 10/31/2008
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): HARWARD, SOREN T
• Application Number:
  US12/290,684
• Publication Number:
  US 20100114546A1
• Time in Patent Office: 2,027 Days
• US Class Current: 702/19
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 5/3015 for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow cell injection devices C12M3/006
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

receiving a first input associated with a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a first subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of predictive regimen parameters from a second subject with one or more similar or dissimilar physical attributes;

determining from the comparison at least one frozen particle therapeutic composition regimen for the first subject the frozen particle therapeutic composition regimen including administering one or more frozen particle therapeutic compositions with a remote controlled robotic pellet gun to the first subject, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent; and

output information.

2. The computer program product of claim 1, wherein the output information is based on the comparison.

3. The computer program product of claim 1, further including:

accessing the first possible dataset in response to the first input.

4. The computer program product of claim 1, further including:

generating the first possible dataset in response to the first input.

5. The computer program product of claim 1, further including:

determining a graphical illustration of the first possible dataset.

6. The computer program product of claim 1, further including:

determining a graphical illustration of the second possible dataset.

7. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

processing a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a first subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of predictive regimen parameters from a second subject with one or more similar or dissimilar physical attributes;

determining from the comparison at least one frozen particle therapeutic composition treatment regimen for the first subject, the at least one frozen particle therapeutic composition treatment regimen including administering one or more frozen particle therapeutic compositions with a remote controlled robotic pellet gun to the first subject, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent; and

output information.

8. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

responding to a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a first subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of predictive regimen parameters for a second subject with one or more similar or dissimilar physical attributes;

determining from the comparison at least one frozen particle therapeutic composition treatment regimen for the first subject, the at least one frozen particle therapeutic composition treatment regimen including administering one or more frozen particle therapeutic compositions with a remote controlled robotic pellet gun to the first subject, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent; and

output information.

9. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

receiving a first input associated with a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of parameters relating to one or more expected biological changes following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic pellet gun to the subject, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

determining from the comparison at least one biological change following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic pellet gun to the subject;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent;

and output information.

10. The computer program product of claim 9, wherein the output information is based on the comparison.

11. The computer program product of claim 9, further including:

accessing the first possible dataset in response to the first input.

12. The computer program product of claim 9, further including:

generating the first possible dataset in response to the first input.

13. The computer program product of claim 9, further including:

determining a graphical illustration of the first possible dataset.

14. The computer program product of claim 9, further including:

determining a graphical illustration of the second possible dataset.

15. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

processing a first input associated with a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of parameters relating to one or more expected biological changes following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic pellet gun to the subject, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

determining from the comparison at least one biological change following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic pellet gun to the subject;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent; and

output information.

16. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

responding to a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of parameters relating to one or more expected biological changes following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic pellet gun to the subject, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

determining from the comparison at least one biological change following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic pellet gun to the subject;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent; and

output information.

17. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

receiving a first input associated with a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a first subject, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

comparing a value associated with the first possible dataset with a second dataset including values representative of predictive regimen parameters from a second subject with one or more similar or dissimilar physical attributes;

determining from the comparison at least one frozen particle therapeutic composition regimen for the first subject the frozen particle therapeutic composition regimen including administering one or more frozen particle therapeutic compositions with a remote controlled robotic high velocity injector to the first subject;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent; and

output information.

18. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

processing a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a first subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of predictive regimen parameters from a second subject with one or more similar or dissimilar physical attributes;

determining from the comparison at least one frozen particle therapeutic composition treatment regimen for the first subject, the at least one frozen particle therapeutic composition treatment regimen including administering one or more frozen particle therapeutic compositions with a remote controlled robotic delivery device, at a velocity of at least 50 meters per second to the first subject, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent; and

output information.

19. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

responding to a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a first subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of predictive regimen parameters for a second subject with one or more similar or dissimilar physical attributes;

determining from the comparison at least one frozen particle therapeutic composition treatment regimen for the first subject, the at least one frozen particle therapeutic composition treatment regimen including administering one or more frozen particle therapeutic compositions with a remote controlled robotic delivery device, at a velocity of at least 50 meters per second to the first subject, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent; and

output information.

20. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

receiving a first input associated with a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of parameters relating to one or more expected biological changes following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic delivery device, at a velocity of at least 50 meters per second to the subject, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

determining from the comparison at least one biological change following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic delivery device, at a velocity of at least 50 meters per second to the subject;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent;

and output information.

21. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

processing a first input associated with a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of parameters relating to one or more expected biological changes following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic delivery device, and at a velocity of at least 50 meters per second, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

determining from the comparison at least one biological change following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic delivery device, and at a velocity of at least 50 meters per second to the subject;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent; and

output information.

22. A non-transitory computer-readable storage medium with an executable program stored thereon, wherein the program instructs a microprocessor to perform the following:

responding to a first possible dataset, the first possible dataset including data representative of one or more measurements relating to one or more physical attributes of a subject;

comparing a value associated with the first possible dataset with a second dataset including values representative of parameters relating to one or more expected biological changes following administration of one or more frozen particle therapeutic compositions with a remote controlled robotic delivery device, and at a velocity of at least 50 meters per second, wherein the one or more frozen particle therapeutic compositions include at least one tracer agent;

determining from the comparison at least one biological change following administration of one or more frozen particle therapeutic compositions with a remote controlled delivery device, and at a velocity of at least 50 meters per second to the subject;

measuring the at least one tracer agent;

communicating real-time feedback control of the amount of frozen particle therapeutic compositions administered to the at least one subject based on the measurement of the at least one tracer agent; and

output information.