Medthods, devices and formulations for targeted endobronchial therapy

• US 8,733,350 B2
• Filed: 08/24/2009
• Issued: 05/27/2014
• Est. Priority Date: 05/06/2002
• Status: Active Grant

• Current Assignee: The Research Foundation for The State University of New York (State University of New York)
• Original Assignee: The Research Foundation for The State University of New York (State University of New York)
• Inventors: Smaldone, Gerald, Palmer, Lucy B.
• Primary Examiner(s): DOUGLAS, STEVEN O
• Application Number:
  US12/546,260
• Publication Number:
  US 20100041766A1
• Time in Patent Office: 1,737 Days
• Field of Search: 128/204.18, 128/204.11, 12820021-20024, 128/911, 128/912, 128/202.27, 12820312-20317, 128/203.26, 128/204.14, 128/207.14, 128/207.16, 128/207.15, 128/DIG.26
• US Class Current: 128/204.18
• CPC Class Codes: A61M 11/00 Sprayers or atomisers specially adapted for therapeutic purposes in general B05B; aerosol containers B65D83/14
• CPC Class Codes: A61M 11/06 of the injector type
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 16/0057 Pumps therefor
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0463 combined with suction tubes, catheters or the like; Outside connections
• CPC Class Codes: A61M 16/0465 Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
• CPC Class Codes: A61M 16/0484 at the distal end
• CPC Class Codes: A61M 16/08 Bellows; Connecting tubes having means for taking samples G01N1/22; Water traps; Patient circuits
• CPC Class Codes: A61M 16/0808 Condensation traps
• CPC Class Codes: A61M 16/0833 T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 11/08 Bronchodilators
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.

Claims

1. A method of treating patients in an ICU, comprising:

a) identifying a mechanically ventilated patient in said intensive care unit being treated with a systemic antibiotic, and

b) administering, in addition, an aerosolized antibiotic to said patient by means of an aerosolizing device.

2. The method of claim 1, wherein a plurality of subjects in the same intensive care unit is being treated with aerosolized antibiotic.

3. The method of claim 2, wherein treating said plurality of subjects in said ICU reduces the incidence of antibiotic-resistant infection in said ICU.

4. The method of claim 1, wherein a plurality of subjects in the same intensive care unit is being treated with both systemic and aerosolized antibiotics.

5. The method of claim 4, wherein treating said plurality of subjects in said ICU reduces the incidence of antibiotic-resistant infection in said ICU.

8. The method of claim 1, wherein said administering is performed while said patient is mechanically ventilated.

6. A method of treating patients in an ICU, comprising:

a) providing a device capable of delivering aerosolized antibiotic, and

b) administering said aerosolized antibiotic to a mechanically ventilated patient in said intensive care unit with said device, wherein a plurality of subjects is treated in the same intensive care unit with both systemic and aerosolized antibiotics.

7. The method of claim 6, wherein treating said plurality of subjects in said ICU reduces the incidence of antibiotic-resistant infection in said ICU.