Real time intravascular monitoring device

• US 8,734,345 B2
• Filed: 08/01/2011
• Issued: 05/27/2014
• Est. Priority Date: 08/01/2011
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Deshpande, Manish, Kapur, Terri A.
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): DANEGA, RENEE A
• Application Number:
  US13/195,287
• Publication Number:
  US 20130035564A1
• Time in Patent Office: 1,030 Days
• Field of Search: 600/309, 600/549
• US Class Current: 600/309
• CPC Class Codes: A61B 10/04 Endoscopic instruments
• CPC Class Codes: A61B 2010/045 Needles pointed biopsy devices with vacuum aspiration A61B10/0283
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/6852 Catheters

Abstract

A real time tissue sampling and analysis system includes a catheter including an elongated body defining at least one internal lumen, a sampling device positionable within the at least one internal lumen of the catheter for collecting a tissue sample, and a biochip disposed within the at least one internal lumen. The biochip includes a substrate for receiving the tissue sample, a marker for interacting with the tissue sample, and a sensor for identifying a characteristic of the tissue sample and transmitting data about the tissue sample to a processing unit for analysis.

Claims

1. A method for determining the morphology of a blood clot in real time, the method comprising:

accessing a vessel containing a blood clot with a catheter, the catheter including an elongate body defining at least one internal lumen and a biochip disposed within the at least one lumen, the biochip including a substrate for receiving a tissue sample, a marker for interacting with the tissue sample, and a sensor for identifying a characteristic of the tissue sample;

obtaining a tissue sample from the blood clot;

subjecting the tissue sample, within the accessed vessel, to the marker; and

measuring the response of the tissue sample to the marker.

2. The method of claim 1, wherein the step of obtaining a tissue sample further includes the step of providing a sampling device within the at least one internal lumen of the catheter.

3. The method of claim 1, wherein the step of obtaining a tissue sample further includes the step of extracting the tissue sample with a sampling device positioned within the at least one internal lumen of the catheter, the sampling device selected from the group consisting of scrapers, forceps, tweezers, and cutters.

4. The method of claim 3, wherein the step of extracting the tissue sample further includes the step of positioning the sampling device proximate to the blood clot.

5. The method of claim 4, wherein the step of subjecting the tissue sample further includes the step of retracting the sampling device proximally within the at least one internal lumen of the catheter so that the tissue sample is positioned proximate to the biochip.

6. The method of claim 1, wherein the step of obtaining a tissue sample further includes the step of aspirating the tissue sample into the at least one internal lumen proximally towards the biochip with one of an aspiration needle, a syringe, and a vacuum.

7. The method of claim 1, further comprising the step of treating the blood clot.