Analytical method and investigation system
First Claim
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1. A system for investigation of the metabolism of a human or animal with regard to a medically significant analyte, comprising:
- a sensor for determining measuring data that are correlated with a concentration of a medically significant analyte in a human or animal body fluid, andan analytical facility for analyzing a series of the measuring data that have been determined by the sensor and are correlated with the concentration of the medically significant analyte in the human or animal body fluid for time points that are distributed over a period of time of at least eight hours, the analytical facility being free from need to obtain a reference value of the medically significant analyte to calibrate the measuring data;
whereby the analytical facility is adapted such that in operation, it selects from the period of time multiple time intervals, which each of the time intervals extend over at least one hour and the analytical facility determines a stability parameter that characterizes the analyte concentration dynamics of change in the time interval for each of the time intervals by analyzing measuring data that are from the time interval, and the analytical facility analyzes the stability parameter and assigns the stability parameter to one of a plurality of predetermined parameter ranges in order to determine disease-related particularities of metabolism.
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Abstract
Metabolism diseases are evaluated by using a sensor to measure concentration of a medically significant analyte in a human or animal body fluid. The measurement data are correlated with the concentration of a medically significant analyte in body fluid over a time period of at least eight hours. An analytical facility analyzes time intervals within the time period to determine a stability parameter that characterizes the analyte concentration dynamics of change. The analytical facility further analyzes the stability parameters to determine disease-related particularities of metabolism.
5 Citations
14 Claims
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1. A system for investigation of the metabolism of a human or animal with regard to a medically significant analyte, comprising:
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a sensor for determining measuring data that are correlated with a concentration of a medically significant analyte in a human or animal body fluid, and an analytical facility for analyzing a series of the measuring data that have been determined by the sensor and are correlated with the concentration of the medically significant analyte in the human or animal body fluid for time points that are distributed over a period of time of at least eight hours, the analytical facility being free from need to obtain a reference value of the medically significant analyte to calibrate the measuring data; whereby the analytical facility is adapted such that in operation, it selects from the period of time multiple time intervals, which each of the time intervals extend over at least one hour and the analytical facility determines a stability parameter that characterizes the analyte concentration dynamics of change in the time interval for each of the time intervals by analyzing measuring data that are from the time interval, and the analytical facility analyzes the stability parameter and assigns the stability parameter to one of a plurality of predetermined parameter ranges in order to determine disease-related particularities of metabolism. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for analyzing a series of measuring data, comprising:
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providing a sensor to determine a series of measuring data; correlating, using a computer program product, the series of measuring data with a concentration of a medically significant analyte in a human or animal body fluid for time points that are distributed over a period of time of at least 8 hours; selecting, using the computer program product, multiple time intervals within the period of time, each time interval extending over at least 1 hour; determining, using the computer program product, a stability parameter through a Fourier transformation of a derivative of the measuring data over time, the stability parameter characterizing dynamics of a change of analyte concentration in each time interval by analyzing measuring data that are from that time interval, performing, using the computer program product, a linear transformation when operating on the measuring data, the linear transformation being performed individually for each time interval; and analyzing, using the computer program product, the stability parameter in order to determine at least one of a diabetic disease and a stage of the diabetic disease, and to further determine a treatment for the diabetic disease. - View Dependent Claims (12)
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13. A system for investigation of the metabolism of a human or animal with regard to a medically significant analyte, comprising:
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a sensor for determining measuring data that are correlated with a concentration of a medically significant analyte in a human or animal body fluid, and means for analyzing a series of measuring data that have been determined by the sensor and are correlated with the concentration of the medically significant analyte in the human or animal body fluid for time points that are distributed over a period of time of at least eight hours by determining a stability parameter that characterizes the analyte concentration dynamics of change and analyzing the stability parameter in order to determine at least one of a diabetic disease, a stage of the diabetic disease, and a treatment for the diabetic disease, wherein the stability parameter is determined through a Fourier transformation of a derivative of the measuring data over time.
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14. A method for analyzing a series of measuring data in human body fluid without calibration, comprising:
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sensing a medically significant analyte in a human body to determine measuring data; correlating a series of the measuring data with a concentration of a medically significant analyte for time points that are distributed over a period of time of at least 8 hours; selecting multiple time intervals each extending over at least a 1 hour the period of time; determining a stability parameter characterizing dynamics of the change of analyte concentration in said time interval for each of the time intervals by analyzing measuring data that are from said time interval, analyzing the stability parameter free from need to obtain a reference value of the medically significant analyte to calibrate the measuring data; and assigning the stability parameter to one of a plurality of predetermined ranges in order to determine disease-related particularities of metabolism.
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Specification