Method and system for patient-specific modeling of blood flow

• US 8,734,356 B2
• Filed: 01/27/2011
• Issued: 05/27/2014
• Est. Priority Date: 08/12/2010
• Status: Active Grant

• Current Assignee: Heartflow Inc.
• Original Assignee: Heartflow Inc.
• Inventors: Taylor, Charles A.
• Primary Examiner(s): Cheng, Jacqueline
• Assistant Examiner(s): Burrage, Michael J
• Application Number:
  US13/014,809
• Publication Number:
  US 20120041735A1
• Time in Patent Office: 1,216 Days
• Field of Search: 600481-508
• US Class Current: 600/507
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Abstract

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient'"'"'s heart, and create a three-dimensional model representing at least a portion of the patient'"'"'s heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient'"'"'s heart and determine a fractional flow reserve within the patient'"'"'s heart based on the three-dimensional model and the physics-based model.

Claims

1. A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method for planning treatment for a patient, the method comprising:

receiving patient-specific data regarding a geometry of an anatomical structure of the patient;

creating a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;

determining first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and a patient-specific physics-based model relating to the anatomical structure of the patient;

creating a reduced-order model of the portion of the anatomical structure by using the first information to define a plurality of resistance values of the reduced-order model;

receiving input from a user selecting a first plan of treatment, the received input including a selection of a desired location for widening of the anatomical structure;

modifying one of the resistance values at a location corresponding to the desired location based on the received input; and

determining second information regarding the blood flow characteristic within the anatomical structure of the patient based on the reduced-order model.

2. The non-transitory computer readable medium of claim 1, wherein the method further includes:

determining a difference between the first information and the second information at a plurality of locations within the anatomical structure of the patient.

3. The non-transitory computer readable medium of claim 1, wherein each of the first information and the second information includes at least one of blood pressure, blood velocity, blood flow rate, or fractional flow reserve within the anatomical structure of the patient.

4. The non-transitory computer readable medium of claim 1, wherein the anatomical structure of the patient includes at least one of a portion of a plurality of arteries in the patient'"'"'s heart, neck, head, thorax, abdomen, arms, or legs.

5. The non-transitory computer readable medium of claim 1, wherein the resistance is modified by decreasing the resistance of the at least one second resistor.

6. The non-transitory computer readable medium of claim 5, the method further comprising:

determining at least one dimension of the widening, the decrease in resistance depending on the at least one determined dimension.

7. The non-transitory computer readable medium of claim 6, wherein the at least one determined dimension includes a length or a diameter.

8. The non-transitory computer readable medium of claim 6, wherein:

the received input from the user includes the at least one dimension; and

the at least one computer system is further configured to determine the at least one dimension based on the received input.

9. A method for planning treatment for a patient using a computer system, the method comprising:

receiving, at least one computer system, patient-specific data regarding a geometry of an anatomical structure of the patient;

creating, using the at least one computer system, a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;

determining, using the at least one computer system, first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and a patient-specific physics-based model relating to the anatomical structure of the patient;

creating, using the at least one computer system, a reduced-order model of the portion of the anatomical structure by using the first information to define a plurality of resistance values of the reduced-order model;

receiving, using the at least one computer system, input from a user selecting a first plan of treatment, the received input including a selection of a desired location for at least one of a bypass or a stent;

modifying, using the at least one computer system, the reduced-order model at a location corresponding to the desired location by at least one of;

adding at least one first resistor at a location corresponding to the desired location based on the received input, or

modifying a resistance of at least one second resistor at the location corresponding to the desired location based on the received input; and

determining, using the at least one computer system, second information regarding the blood flow characteristic within the anatomical structure of the patient based on the reduced-order model.

10. The method of claim 9, wherein the reduced-order model is a lumped parameter model.

11. The method of claim 9, wherein the at least one first resistor is added parallel to a portion of the reduced-order model.

12. The method of claim 11, wherein the at least one first resistor has a lower resistance than the portion of the reduced-order model that is parallel to the at least one first resistor.

13. A system for planning treatment for a patient, the system comprising:

at least one computer system configured to;

receive patient-specific data regarding a geometry of an anatomical structure of the patient;

create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;

determine first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and a patient-specific physics-based model relating to the anatomical structure of the patient;

create a reduced-order model of the portion of the anatomical structure by using the first information to define a plurality of resistance values of the reduced-order model;

receive input from a user selecting a first plan of treatment, the received input including a selection of a desired location for at least one of a stent or a bypass;

at least one of adding at least one first resistor at a location in the reduced-order model corresponding to the desired location based on the received input, or modifying a resistance of at least one second resistor at the location in the reduced-order model corresponding to the desired location based on the received input; and

determine second information regarding the blood flow characteristic within the anatomical structure of the patient based on the reduced-order model.

14. The system of claim 13, wherein the at least one computer system is further configured to modify the resistance of the at least one second resistor by decreasing the resistance of the at least one second resistor.

15. The system of claim 14, wherein the at least one computer system is further configured to determine at least one dimension of the stent, and the decrease in resistance depends on the at least one determined dimension.

16. The system of claim 15, wherein the at least one determined dimension includes a length or a diameter.

17. The system of claim 15, wherein:

the received input from the user includes the at least one dimension of the stent; and

the at least one computer system is further configured to determine the at least one dimension based on the received input.

18. The system of claim 15, wherein:

the received input from the user includes a selection of one of a plurality of stents; and

the at least one computer system is further configured to determine the at least one dimension based on the selected stent.

19. The system of claim 13, wherein the at least one computer system is further configured to:

determine a difference between the first information and the second information at a plurality of locations within the anatomical structure of the patient.

20. The system of claim 13, wherein each of the first information and the second information includes at least one of blood pressure, blood velocity, blood flow rate, or fractional flow reserve within the anatomical structure of the patient.

21. The system of claim 13, wherein the anatomical structure of the patient includes at least one of a portion of a plurality of arteries in the patient'"'"'s heart, neck, head, thorax, abdomen, arms, or legs.