Method and system for patient-specific modeling of blood flow

• US 8,734,357 B2
• Filed: 01/27/2011
• Issued: 05/27/2014
• Est. Priority Date: 08/12/2010
• Status: Active Grant

• Current Assignee: Heartflow Inc.
• Original Assignee: Heartflow Inc.
• Inventors: Taylor, Charles A.
• Primary Examiner(s): Cheng, Jacqueline
• Assistant Examiner(s): Burrage, Michael J
• Application Number:
  US13/014,821
• Publication Number:
  US 20120041318A1
• Time in Patent Office: 1,216 Days
• Field of Search: 600481-508
• US Class Current: 600/507
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Abstract

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient'"'"'s heart, and create a three-dimensional model representing at least a portion of the patient'"'"'s heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient'"'"'s heart and determine a fractional flow reserve within the patient'"'"'s heart based on the three-dimensional model and the physics-based model.

Claims

1. A system for planning treatment for a patient, the system comprising:

at least one computer system configured to;

receive patient-specific data regarding a geometry of an anatomical structure of the patient;

create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;

determine first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and patient-specific information regarding a physiological condition of the patient;

generate a reduced-order model of the portion of the anatomical structure by using the first information to define one or more parameters of the reduced-order model;

modify one or more of the parameters of the reduced-order model based on a modeled administration of medication to the patient; and

determine second information regarding the blood flow characteristic within the anatomical structure of the patient based on the modified one or more parameters of the reduced-order model.

2. The system of claim 1, wherein the at least one computer system is configured to modify the information of the physiological condition of the patient based on input received from a user, the input including a selection of a plan for treating the patient with medication.

3. The system of claim 2, wherein:

the selected plan for treating the patient further includes a change in at least one of a cardiac output, a level of exercise, or a level of hyperemia; and

the at least one computer system is further configured to modify the information of the physiological condition of the patient based on the selected plan of treatment.

4. The system of claim 3, wherein the at least one computer system is further configured to modify the information of the physiological condition of the patient by changing a parameter relating to blood flow through the anatomical structure of the patient.

5. The system of claim 4, wherein the changed parameter relating to blood flow includes at least one of a coronary artery resistance, an aortic blood pressure, or a heart rate.

6. The system of claim 1, wherein the at least one computer system is further configured to:

determine a difference between the first information and the second information at a plurality of locations within the anatomical structure of the patient.

7. The system of claim 1, wherein each of the first information and the second information includes at least one of blood pressure, blood velocity, blood flow rate, or fractional flow reserve within the anatomical structure of the patient.

8. The system of claim 1, wherein the anatomical structure of the patient includes at least one of a portion of a plurality of arteries in the patient'"'"'s heart, neck, head, thorax, abdomen, arms, or legs.

9. A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method for planning treatment for a patient, the method comprising:

receiving patient-specific data regarding a geometry of an anatomical structure of the patient;

creating a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;

determining first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and patient-specific information regarding a physiological condition of the patient;

generating a reduced-order model of the portion of the anatomical structure by using the first information to define one or more parameters of the reduced-order model; and

determining second information regarding the blood flow characteristic within the anatomical structure of the patient based on a desired modeled change in one or more parameters of the reduced-order model based on a modeled administration of medication to the patient.

10. The non-transitory computer readable medium of claim 9, wherein the second information is determined based further on a selected plan of treatment associated with a change in at least one of a cardiac output, a heart rate, a stroke volume, a blood pressure, a level of exercise or exertion, or a level of hyperemia for the patient.

11. The non-transitory computer readable medium of claim 10, wherein the method further comprises modifying the information regarding the physiological condition of the patient by changing a parameter relating to blood flow through the anatomical structure of the patient.

12. The non-transitory computer readable medium of claim 11, the changed parameter relating to blood flow includes at least one of a coronary artery resistance, an aortic blood pressure, or a heart rate.

13. The non-transitory computer readable medium of claim 9 wherein the method further includes:

determining a difference between the first information and the second information at a plurality of locations within the anatomical structure of the patient.

14. The non-transitory computer readable medium of claim 9, wherein each of the first information and the second information includes at least one of blood pressure, blood velocity, blood flow rate, or fractional flow reserve within the anatomical structure of the patient.

15. The non-transitory computer readable medium of claim 9, wherein the anatomical structure of the patient includes at least one of a portion of a plurality of arteries in the patient'"'"'s heart, neck, head, thorax, abdomen, arms, or legs.

16. A method for planning treatment for a patient using at least one computer system, the method comprising:

receiving, at least one computer system patient-specific data regarding a geometry of an anatomical structure of the patient;

creating, using the at least one computer system, a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data;

determining, using the at least one computer system, first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three-dimensional model and patient-specific information regarding a physiological condition of the patient;

generating, using the at least one computer system, a reduced-order model of the portion of the anatomical structure by using the first information to define one or more parameters of the reduced-order model;

modifying, using the at least one computer system, one or more of the parameters of the reduced-order model based on a modeled administration of medication to the patient; and

determining, using the at least one computer system, second information regarding the blood flow characteristic within the anatomical structure of the patient based on the modified one or more parameters of the reduced-order model.

17. The method of claim 16, wherein:

modifying the physiological condition of the patient further includes changing a parameter relating to blood flow through the anatomical structure of the patient; and

the changed parameter includes at least one of a coronary artery resistance, an aortic blood pressure, or a heart rate.

18. The method of claim 16, further comprising:

creating, using the at least one computer system, a three-dimensional simulation including the first information; and

creating, using the at least one computer system, a reduced-order model based on the three-dimensional simulation;

wherein the second information is determined using the reduced-order model.

19. The method of claim 18, wherein the reduced-order model is a lumped parameter model.

20. The method of claim 16, wherein modifying the physiological condition of the patient is based on a first input received from the user, the first input indicating a first plan of treatment selected by the user, and the method further comprises:

modifying, using the at least one computer system, the physiological condition of the patient separately from the first input and based on a second input received from the user, the second input indicating a second plan of treatment selected by the user; and

determining, using the at least one computer system, third information regarding the blood flow characteristic within the anatomical structure of the patient based on the physiological condition modified based on the second input; and

comparing the first and second plans of treatment by comparing the second information and the third information.