Percussion assisted angiogenesis

• US 8,734,368 B2
• Filed: 07/11/2008
• Issued: 05/27/2014
• Est. Priority Date: 09/04/2003
• Status: Active Grant

• Current Assignee: Simon Fraser University
• Original Assignee: Simon Fraser University
• Inventors: Hoffmann, Andrew Kenneth
• Primary Examiner(s): KISH, JAMES M
• Application Number:
  US12/218,054
• Publication Number:
  US 20080275343A1
• Time in Patent Office: 2,146 Days
• Field of Search: 600/439, 601/2
• US Class Current: 601/2
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/0883 for diagnosis of the heart
• CPC Class Codes: A61B 8/0891 for diagnosis of blood vessels
• CPC Class Codes: A61B 8/4455 Features of the external shape of the probe, e.g. ergonomic aspects
• CPC Class Codes: A61B 8/483 involving the acquisition of a 3D volume of data
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

The present invention relates to a new non-invasive method for inducing angiogenesis and more particularly coronary angiogenesis wherein an operator applies localized percussion upon the upper torso proximate an ischemic myocardial region, whereby the percussive forces penetrate to cause sheer stresses to the endothelium of the coronaries which lie thereupon, and thereby cause new coronary growth by virtue of endogenous liberation of beneficial angiogenic mediators. A pair of vibratory contacts are advantageously applied to rib-spaces to either side of the sternum (or alternatively to the upper back), where-after percussion is applied at the resonance frequency of the heart/epimyocardium at a displacement amplitude of 0.1 mm-15 mm (preferably greater than 1 mm), such as to maximize an internal oscillatory effect. The system is also adaptable for cerebral and peripheral vasculature applications. Ultrasonic imaging may optionally be utilized to direct percussive therapy.

Claims

1. A non-invasive method for inducing growth of coronary arterial blood vessels, comprising the steps of:

providing means for delivering percussion upon an external body surface of an individual with a waveform and serial impact frequency in the range of 1 Hz to 200 Hz, and a displacement amplitude in the range of 1 mm-15 mm, and

applying a series of consecutive, localized percussions at a waveform and serial impact frequency in the range of 1-200 cycles per second and a displacement amplitude in the range of 1 mm-15 mm, to an external body surface deemed to overlie a diseased coronary arterial vasculature supplying a heart in need of growth of coronary arterial blood vessels, whereby forces of said series of consecutive, localized percussions penetrate from said external body surface to said diseased coronary arterial vasculature, such as to induce growth of coronary arterial blood vessels within said diseased coronary arterial vasculature,

wherein said means for delivering percussion comprises at least one contact node adapted to enable operative seating against at least one of a chest wall and an upper back external body surface of a patient receiving said series of consecutive percussions from said means for delivering percussion, wherein said contact node delivers said series of consecutive percussions.

2. The method of claim 1, wherein said series of consecutive, localized percussions are applied at a displacement amplitude of at least 4 mm.

3. The method of claim 1, wherein said series of consecutive, localized percussions are applied at a frequency of at least 8 impacts per second.

4. The method of claim 1, wherein said series of consecutive, localized percussions are delivered via a vibratory waveform comprising a first lower frequency modulated upon a second higher frequency, whereby said first and second frequencies lie in a range of frequencies consistent with a cardiac related resonance frequency.

5. The method of claim 2, wherein said external body surface comprises the upper back of a patient receiving said series of consecutive, localized percussions.

6. The method of claim 1, further comprising the step of selectively limiting said percussions during a systole of said patient.

7. A method for inducing growth of coronary blood vessels, comprising the steps of:

a) providing means for delivering percussion comprising a percussion device operable to deliver mechanical oscillations with a waveform and serial impact frequency in the range of 1 Hz to 200 Hz, and

b) delivering a series of consecutive percussions at a frequency in the range of 1-200 Hz and a displacement amplitude in the range of 1 mm-15 mm via said percussion device locally upon an upper torso overlying the thoracic cavity of a patient in need of growth of coronary blood vessels, whereby said series of consecutive percussions penetrate to a diseased coronary vasculature such as to induce growth of coronary blood vessels,

wherein said percussion device has at least one contact node adapted to enable operative seating against at least one of a chest wall and upper back of said upper torso of said patient receiving said series of consecutive percussions from said percussion device, and wherein said contact node delivers said series of consecutive percussions.

8. The method of claim 7, wherein said series of consecutive percussions are applied at a displacement amplitude of at least 2 mm.

9. The method of claim 7 wherein said series of consecutive percussions are applied with a repetitive impact frequency of at least 20 impacts per second.

10. The method of claim 7, wherein said at least one contact node is adapted to enable operative seating within a rib space of said patient.

11. The method of claim 7, wherein said percussion device has at least a pair of contact nodes spaced to enable seating across a sternum of said patient receiving said series of consecutive percussions from said percussion device, wherein said contact nodes jointly deliver said series of consecutive percussions.

12. The method of claim 7, wherein said percussion device has a plurality of contact nodes spaced to enable seating upon a plurality of rib spaces at differing intercostal space levels of said patient receiving said series of consecutive percussions from said percussion device, wherein said plurality of contact nodes jointly deliver said series of consecutive percussions.

13. The method of claim 7, wherein said percussion device has at least one percussive contact comprising an ultrasonic imaging transducer, whereby said ultrasonic imaging transducer delivers said series of consecutive percussions from said percussion device to said upper torso, thereby enabling targeting of said series of consecutive percussions via a real time image produced on an ultrasonic display.

14. The method of claim 7, wherein said series of consecutive percussions are applied at a displacement amplitude of at least 4 mm.

15. The method of claim 7, wherein said growth of coronary blood vessels comprises at least one of growth of new coronary blood vessels, and growth of pre-existing collaterals.

16. The method of claim 7, wherein said series of consecutive percussions are selectively limited during at least a portion of a systole of the cardiac cycle of said patient receiving percussion from said percussion device.

17. The method of claim 7, further comprising the step of manually applying an engagement force upon said percussion device during delivery of said series of consecutive percussions operable to provide therapeutic penetration of said series of consecutive percussions to within said thoracic cavity.

18. The method of claim 7, wherein said percussions are applied to at the said upper back of said patient receiving said series of consecutive percussions from said percussion device.

19. A non-invasive method for inducing coronary arterial growth comprising the steps of:

a) providing means for delivering percussion comprising a hand held percussion device operable to deliver low frequency infrasonic to sonic mechanical percussion with a waveform and serial impact frequency in the 1-200 Hz range and a stroke length in the 1 mm to 15 mm range,

b) engaging said percussion device to an upper torso overlying the thoracic cavity of an individual in need of coronary arterial growth,

c) delivering said percussion via said percussion device to said upper torso while manually controlling an engagement force of said percussion device against said upper torso by the hand of an operator, and

d) inspecting for evidence of transmission of said percussion within said individual to confirm satisfactory engagement of said percussion device, whereby said percussion penetrates to the coronary vasculature of said patient such as to induce coronary arterial growth

wherein said hand held percussion device comprises at least one contact node adapted to enable operative seating within a rib space on said upper torso overlying the thoracic cavity of said patient receiving said percussion from said percussion device, wherein said contact node delivers said percussion.

20. A method for inducing growth of coronary blood vessels, comprising the steps of:

providing means for delivering percussion comprising a percussion device operable to deliver percussion with a waveform and serial impact frequency in the 1 Hz to 200 Hz range;

non-invasively applying said percussion with a palpable displacement amplitude in the range of 1 mm to 15 mm locally upon an upper torso overlying the thoracic cavity of a patient having a diseased coronary vasculature in need of growth of coronary blood vessels, wherein the forces of said percussion penetrate to said diseased coronary vasculature, such as to induce growth of coronary blood vessels within said diseased coronary vasculature; and

wherein said percussion device comprises at least one contact node adapted to enable operative seating within a rib space on said upper torso overlying the thoracic cavity of said patient receiving said percussion from said percussion device, wherein said contact node delivers said percussion.

21. The method of claim 20, wherein said percussion has a displacement amplitude of at least 2 mm, and is applied locally to at least one of a chest wall and upper back of a patient receiving said percussion.

22. The method of claim 21, wherein said percussion is applied with an impact frequency of at least 20 impacts per second.

23. A method for inducing neo-coronary arterial growth comprising the steps of:

providing a means for delivering non-invasive localized transthoracic vibration with a waveform and serial impact frequency in the range of 8 Hz to 120 Hz, and a stroke length within the range of 1 mm to 15 mm, and applying said vibration locally to at least one of a chest wall and upper back of an individual receiving said vibration, wherein the emissions of said vibration are selectively limited during a systole of the cardiac cycle of said individual, and

wherein said means for delivering localized transthoracic vibration comprises at least one contact adapted to enable operative, localized seating against at least one of a chest wall and upper back of said individual receiving said vibration, wherein said contact delivers said vibration.

24. The method of claim 23, wherein said vibration is applied repeatedly at an impact frequency of at least 20 cycles per second.

25. The method of claim 23, wherein said vibration is emitted in a randomized manner.