Tissue cassette for automated handling and embedding of tissue samples

• US 8,734,735 B2
• Filed: 03/14/2011
• Issued: 05/27/2014
• Est. Priority Date: 09/26/2002
• Status: Expired due to Term

• Current Assignee: Biopath Automation, LLC
• Original Assignee: Biopath Automation, LLC
• Inventors: Williamson, Warren P. IV, Ward, Thomas J., Whitlatch, Stephen P.
• Primary Examiner(s): Nagpaul, Jyoti
• Application Number:
  US13/047,044
• Publication Number:
  US 20110182783A1
• Time in Patent Office: 1,170 Days
• Field of Search: 422 63- 67, 422/536, 422/50, 422/500, 436/180
• US Class Current: 422/536
• CPC Class Codes: G01N 1/36 Embedding or analogous mounting of samples
• CPC Class Codes: G01N 2001/366 Moulds; Demoulding
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers
• CPC Class Codes: Y10T 436/2525 Stabilizing or preserving
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.

Claims

1. A cassette for holding a tissue sample during a microtome slicing operation in which the cassette and the tissue sample are sliced prior to mounting and examination of the tissue sample on a microscope slide, the cassette comprising:

a microtome sectionable body including a sectionable bottom wall and at least one sectionable side wall extending upwardly with respect to said sectionable bottom wall to define an interior space for receiving the tissue sample, whereby the microtome sectionable body and the tissue sample are together sectionable with a microtome for mounting a sliced section of the tissue sample on the microscope slide; and

a sensing element on said microtome sectionable body and configured to allow an automated sensing system to detect a first physical configuration and a second, different physical configuration of the cassette.

2. The cassette of claim 1, wherein the sensing element is machine readable.

3. The cassette of claim 1, wherein the sensing element comprises machine readable indicia.

4. The cassette of claim 1, in combination with a frame, said frame receiving said microtome sectionable body in a manner allowing movement of said body from a first position to a second position suitable for microtome sectioning of said body.

5. The cassette of claim 1, wherein the sensing element is configured to detect the size of the cassette.

6. The cassette of claim 1, wherein the sensing element is configured to detect the shape of the cassette.