Hyaluronic acid based copolymers
First Claim
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1. A hyaluronic acid (HA) conjugate comprising the reaction product of a moiety derived from HA and a moiety derived from poly(ethylene glycol) (PEG);
- wherein the moiety derived from HA is a HA functionalized to bear a terminal amine group, a terminal anhydride group, or a terminal aldehyde group, wherein the moiety derived from PEG is a PEG functionalized to bear a terminal aldehyde group, a succinamide group, or a terminal amine group;
wherein the resulting HA conjugate with PEG is end-capped with a species selected from the group consisting of fatty acid, fatty alcohol, poly(ester amide) that may optionally contain alkyl, amino acid, PEG or alcohol group, polycaprolactone, polylactide, polyglycolide, polyhydroxyalkanoate (PHA), polydioxanone (PDS), or PHA-PEG.
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Abstract
Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
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10 Claims
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1. A hyaluronic acid (HA) conjugate comprising the reaction product of a moiety derived from HA and a moiety derived from poly(ethylene glycol) (PEG);
- wherein the moiety derived from HA is a HA functionalized to bear a terminal amine group, a terminal anhydride group, or a terminal aldehyde group, wherein the moiety derived from PEG is a PEG functionalized to bear a terminal aldehyde group, a succinamide group, or a terminal amine group;
wherein the resulting HA conjugate with PEG is end-capped with a species selected from the group consisting of fatty acid, fatty alcohol, poly(ester amide) that may optionally contain alkyl, amino acid, PEG or alcohol group, polycaprolactone, polylactide, polyglycolide, polyhydroxyalkanoate (PHA), polydioxanone (PDS), or PHA-PEG. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- wherein the moiety derived from HA is a HA functionalized to bear a terminal amine group, a terminal anhydride group, or a terminal aldehyde group, wherein the moiety derived from PEG is a PEG functionalized to bear a terminal aldehyde group, a succinamide group, or a terminal amine group;
Specification