Device including altered microorganisms, and methods and systems of use
First Claim
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1. An implantable device, comprising:
- at least one semi-permeable barrier of a polymer film or thermoplastic hollow fibers substantially enclosing at least one first auxotrophic microorganism and at least one second auxotrophic microorganism, the at least one first auxotrophic microorganism including at least one nucleic acid construct encoding at least one first vaccine therapeutic agent and located in a first compartment, the barrier defining an interior region and exterior region; and
a peristaltic pump for dispensing the at least one first vaccine therapeutic agent;
wherein the device includes at least one metabolite required by at least one auxotrophic microorganism; and
the at least one second auxotrophic microorganism including at least one nucleic acid construct encoding at least one second vaccine and located in a second compartment;
wherein the first and second compartments are configured to release the first vaccine prior to the second vaccine.
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Abstract
Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent.
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Citations
49 Claims
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1. An implantable device, comprising:
at least one semi-permeable barrier of a polymer film or thermoplastic hollow fibers substantially enclosing at least one first auxotrophic microorganism and at least one second auxotrophic microorganism, the at least one first auxotrophic microorganism including at least one nucleic acid construct encoding at least one first vaccine therapeutic agent and located in a first compartment, the barrier defining an interior region and exterior region; and
a peristaltic pump for dispensing the at least one first vaccine therapeutic agent;
wherein the device includes at least one metabolite required by at least one auxotrophic microorganism; and
the at least one second auxotrophic microorganism including at least one nucleic acid construct encoding at least one second vaccine and located in a second compartment;
wherein the first and second compartments are configured to release the first vaccine prior to the second vaccine.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
Specification