Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
First Claim
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1. A method of coating a catheter balloon comprising:
- coating a catheter balloon with a coating solution comprising iodine, an organic solvent, a substantially water-insoluble therapeutic agent, and a copolymer comprising poly(HEMA) and a monomer selected from the group consisting of glycidyl methacrylate and acrylic acid; and
drying the catheter balloon to form a water soluble coating on the catheter balloon,wherein the copolymer is complexed with the iodine in the water soluble coating.
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Abstract
A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.
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Citations
22 Claims
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1. A method of coating a catheter balloon comprising:
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coating a catheter balloon with a coating solution comprising iodine, an organic solvent, a substantially water-insoluble therapeutic agent, and a copolymer comprising poly(HEMA) and a monomer selected from the group consisting of glycidyl methacrylate and acrylic acid; and drying the catheter balloon to form a water soluble coating on the catheter balloon, wherein the copolymer is complexed with the iodine in the water soluble coating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of coating a catheter balloon comprising:
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coating a catheter balloon with a coating solution comprising iodine, an organic solvent, a substantially water-insoluble therapeutic agent, and a copolymer comprising poly(HEMA) and a monomer selected from the group consisting of glycidyl methacrylate and acrylic acid; and drying the catheter balloon to form a water soluble coating on the catheter balloon, wherein the iodine is non-covalently bound in the water soluble coating. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification