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Method for forming a molecularly imprinted polymer biosensor

  • US 8,734,890 B2
  • Filed: 09/24/2010
  • Issued: 05/27/2014
  • Est. Priority Date: 09/16/2009
  • Status: Active Grant
First Claim
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1. A method for forming a molecularly imprinted polymer biosensor, comprising:

  • (a) preparing a reaction solution including an imprinting molecule, a functional monomer, an initiator, and a crosslinking agent, wherein a molar ratio of the imprinting molecule, the functional monomer, the initiator and the crosslinking agent with respect to each other in the reaction solution ranges from about 1;

    4;

    30;

    0.17 to 1;

    4;

    30;

    0.85;

    (b) disposing the reaction solution in a space between upper and lower substrates each of which is made of a light-transmissible material;

    (c) disposing on the upper substrate a photomask having a patterned hole;

    (d) irradiating the reaction solution through the patterned hole of the photomask and the upper substrate so that the reaction solution undergoes polymerization to form a polymer between the upper and lower substrates, wherein step (d) is conducted with an irradiation energy ranging from 16 J/cm2 to 72 J/cm2;

    (e) removing the upper substrate after the polymer is formed on the lower substrate; and

    (f) extracting the imprinting molecule from the polymer so that a patterned molecularly imprinted polymer film is formed on the lower substrate.

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